EndoCannabinoid System

The Endocannabinoid System and why so few people know about it

If you’d asked me a year ago about the endocannabinoid system, I would have stared at you blankly while uttering a confused ‘endo-what?’

That’s not to say I’m someone who has no clue about health. As an ex-bodyworker, my training involved learning about all the major systems in the body, or so I thought. But before entering the world of medical cannabis, the endocannabinoid system just wasn’t on my radar.

And I’m not alone. Most people I know have no knowledge of this integral biological system. And like me, with even the briefest of explanations, their eyes light up in wonder and curiosity. It’s as if suddenly everything makes sense, with the proverbial ‘aha’ moment – “Oh right, that’s why cannabis helps so many conditions’.

So, a year into my cannabis immersion, I wanted to get to the bottom of the question: why do so few people know about the endocannabinoid system (ECS)?

Scientists discover endocannabinoid system through studying Cannabis

A first clue lies in the manner in which the endocannabinoid system1 was discovered. Since the 1960s, scientists had been studying the active compounds in cannabis; and it was through their quest to understand how THC worked in the body that they found the first cannabinoid receptor in 1988.

This was followed by the identification of the body’s own cannabis-like chemicals that, like THC, fitted into the cannabinoid receptors causing physiological changes in the body. The resulting communication network located primarily in the brain, central nervous and immune system became known as the endocannabinoid system (ECS). Its role – to act as a biological regulator, ensuring that balance is achieved in the body.

The ECS is implicated in everything from chronic pain, tumor growth, metabolic diseases, anxiety, and epilepsy. Scientists have seen that compounds within the cannabis plant interact with the ECS, and in the process ease symptoms such as nausea during chemotherapy, chronic pain and can even reduce epileptic seizures.

Schedule 1 status restricts research

And yet, these very compounds are classified as having no accepted medical use2, a decision made prior to the discovery of the endocannabinoid system.

According to Greg Gerdeman, Assistant Professor in Biology at Eckerd College in Florida, “The thing is that the schedule 1 status is so extreme that it creates all of these barriers to research. The DEA has stonewalled researchers to be able to look at herbal cannabis and study its outcomes. For this reason, just the whole intensity of the scheduling has made it difficult to make progress.”3

By progress we can talk in terms of understanding the full extent of the workings of the ECS, researching therapeutic properties of cannabis that are not related to its abuse, and getting herbal cannabis-based medication through all the appropriate protocols; such as double-blind, randomized, three-stage clinical trials.

Doctors lack knowledge

This lack of herbal cannabis medication on the market is a major contributing factor to why so little is known about the ECS in medical circles. According to Gerdeman, an average doctor in the US gets much of their information about advances in medicine from drug reps who have a product under development.

Right now, due in part to the schedule 1 status, selling herbal cannabis products is not on the pharmaceutical companies’ agenda, and so the only information that reaches doctors about cannabis is regarding its potential harm.

However, in states and countries where medical cannabis has been legalized and commercial cannabis-based products are on the market; doctors are clamoring for more information about the ECS and the medicinal uses of cannabis. In Israel, for instance, the Ministry of Health’s Medical Cannabis Unit trains doctors so that they can prescribe medical cannabis for patients with qualifying conditions.

Medical students sitting and talking at the university

Is the endocannabinoid system taught at medical school?

But what about the doctors of the future? Will the endocannabinoid system feature on their med school curriculum?

Back in 2013, David B. Allen MD commissioned a survey in which all the medical schools in the US were asked whether they included the ECS within their syllabus.4 Only 13% were found to teach it in any way, with Dr. Allen declaring that “research and education of medical students involving the ECS is being intentionally restricted by politics.”

This finding sent shock waves through the medical cannabis community, with many wondering what hope there was for an integration of medical cannabis into the healthcare system if most health professionals were unaware of the physiological system underpinning its effectiveness.

Moving in right direction

Thankfully, four years on, there are signs of progress. According to Gerdeman: “Awareness is growing. The neuroscience textbook that I teach my undergraduate neuroscience course with, and is the most popular undergraduate neuroscience textbook … has three pages on endocannabinoids. It cites my work and others calling it, ‘The most exciting discovery in cell signaling in the past several years.’”

In other countries such as the UK and Spain, the endocannabinoid system is taught in many if not all medical schools, although surprisingly in Israel, it is not.

Could more knowledge of the ECS change cannabis scheduling?

So, whatever way you look at it, the therapeutic future of both the endocannabinoid system and the cannabis plant are defined by what is essentially outdated drug scheduling. But could a greater knowledge of the ECS allow cannabis to come out of its 50-year hinterland?

Gerdeman thinks this could be the case. “Discovering the ECS is liberating cannabis from the schedule 1 paradigm where it hasn’t really ever belonged,” he says. “And naturally it feeds into the narrative that cannabis in some shape or form could be beneficial to so many different people.”

It would follow then that as more knowledge of the endocannabinoid system seeps out of the research labs into the knowledge bank of doctors and the public at large, a change in scheduling of cannabis might just follow.

So, it’s time to go forth and publicize our neglected, biological best friend, the endocannabinoid system. Get informed, spread the word, and let’s help give the ECS the recognition it deserves.

About the Author:

Mary Biles is a British freelance writer-blogger and wandering spirit, mostly based in the Andalusian capital of Seville, Southern Spain. She is passionate about the healing potential of cannabis and is currently a guest blogger for CBD oil innovators Endoca.

 


References:

1.
Nicke D. Marijuana Your Body Makes – Endocannabinoids | The Cannapedia. The Cannapedia. http://thecannapedia.org/marijuana-your-body-makes-endocannabinoids/. Published November 5, 2016. Accessed June 18, 2017.
2.
Controlled Substances Act – Wikipedia. Wikipedia. https://en.wikipedia.org/wiki/Controlled_Substances_Act. Accessed June 18, 2017.
3.
Gregory Gerdeman. Biology | Eckerd College. https://www.eckerd.edu/biology/faculty/gerdeman/. Accessed June 18, 2017.
4.
B. Allen, M.D. D. Survey Shows Low Acceptance of the Science of the ECS (Endocannabinoid System). Outword Magazine. http://www.outwordmagazine.com/inside-outword/glbt-news/1266-survey-shows-low-acceptance-of-the-science-of-the-ecs-endocannabinoid-system. Accessed June 18, 2017.
10 replies
  1. jordan keffer
    jordan keffer says:

    great article, not a lot of people bringing awareness about the endocannabinoid system, schools should be teaching medical student a lot more about it because how can a doctor prescribe medicinal marijuana to a patient without having an understanding of the ECS?

    Reply
    • Mary Biles
      Mary Biles says:

      Thanks so much for your comments Jordan. I think all those that know even a little bit about the endocannabinoid system have to go out and spread the word. Of course it needs to be taught at medical school as well and incorporated in doctors continued professional development. All power to the ECS!

      Reply
    • Mary Biles
      Mary Biles says:

      Thanks Rose. Glad you enjoyed the article. Yes, it’s a curious state of affairs when a patent is taken out by the US federal government on something that has no accepted therapeutic value.

      Reply
  2. Jay Breese
    Jay Breese says:

    Strangely it’s not taught in Israeli medical school curriculum while it was discovered there in ’88. Strange and ironic to say the least.

    Reply
    • Mary Biles
      Mary Biles says:

      Hi Jay, I totally agree. I spoke to Michael Dor, the head of the medical cannabis unit in Israel and asked him if the ECS was taught at medical school. I was as surprised as you were when he said it wasn´t.

      Reply

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