EndoCannabinoid System

The Endocannabinoid System and why so few people know about it

If you’d asked me a year ago about the endocannabinoid system, I would have stared at you blankly while uttering a confused ‘endo-what?’

That’s not to say I’m someone who has no clue about health. As an ex-bodyworker, my training involved learning about all the major systems in the body, or so I thought. But before entering the world of medical cannabis, the endocannabinoid system just wasn’t on my radar.

And I’m not alone. Most people I know have no knowledge of this integral biological system. And like me, with even the briefest of explanations, their eyes light up in wonder and curiosity. It’s as if suddenly everything makes sense, with the proverbial ‘aha’ moment – “Oh right, that’s why cannabis helps so many conditions’.

So, a year into my cannabis immersion, I wanted to get to the bottom of the question: why do so few people know about the endocannabinoid system (ECS)?

Scientists discover endocannabinoid system through studying Cannabis

A first clue lies in the manner in which the endocannabinoid system1 was discovered. Since the 1960s, scientists had been studying the active compounds in cannabis; and it was through their quest to understand how THC worked in the body that they found the first cannabinoid receptor in 1988.

This was followed by the identification of the body’s own cannabis-like chemicals that, like THC, fitted into the cannabinoid receptors causing physiological changes in the body. The resulting communication network located primarily in the brain, central nervous and immune system became known as the endocannabinoid system (ECS). Its role – to act as a biological regulator, ensuring that balance is achieved in the body.

The ECS is implicated in everything from chronic pain, tumor growth, metabolic diseases, anxiety, and epilepsy. Scientists have seen that compounds within the cannabis plant interact with the ECS, and in the process ease symptoms such as nausea during chemotherapy, chronic pain and can even reduce epileptic seizures.

Schedule 1 status restricts research

And yet, these very compounds are classified as having no accepted medical use2, a decision made prior to the discovery of the endocannabinoid system.

According to Greg Gerdeman, Assistant Professor in Biology at Eckerd College in Florida, “The thing is that the schedule 1 status is so extreme that it creates all of these barriers to research. The DEA has stonewalled researchers to be able to look at herbal cannabis and study its outcomes. For this reason, just the whole intensity of the scheduling has made it difficult to make progress.”3

By progress we can talk in terms of understanding the full extent of the workings of the ECS, researching therapeutic properties of cannabis that are not related to its abuse, and getting herbal cannabis-based medication through all the appropriate protocols; such as double-blind, randomized, three-stage clinical trials.

Doctors lack knowledge

This lack of herbal cannabis medication on the market is a major contributing factor to why so little is known about the ECS in medical circles. According to Gerdeman, an average doctor in the US gets much of their information about advances in medicine from drug reps who have a product under development.

Right now, due in part to the schedule 1 status, selling herbal cannabis products is not on the pharmaceutical companies’ agenda, and so the only information that reaches doctors about cannabis is regarding its potential harm.

However, in states and countries where medical cannabis has been legalized and commercial cannabis-based products are on the market; doctors are clamoring for more information about the ECS and the medicinal uses of cannabis. In Israel, for instance, the Ministry of Health’s Medical Cannabis Unit trains doctors so that they can prescribe medical cannabis for patients with qualifying conditions.

Medical students sitting and talking at the university

Is the endocannabinoid system taught at medical school?

But what about the doctors of the future? Will the endocannabinoid system feature on their med school curriculum?

Back in 2013, David B. Allen MD commissioned a survey in which all the medical schools in the US were asked whether they included the ECS within their syllabus.4 Only 13% were found to teach it in any way, with Dr. Allen declaring that “research and education of medical students involving the ECS is being intentionally restricted by politics.”

This finding sent shock waves through the medical cannabis community, with many wondering what hope there was for an integration of medical cannabis into the healthcare system if most health professionals were unaware of the physiological system underpinning its effectiveness.

Moving in right direction

Thankfully, four years on, there are signs of progress. According to Gerdeman: “Awareness is growing. The neuroscience textbook that I teach my undergraduate neuroscience course with, and is the most popular undergraduate neuroscience textbook … has three pages on endocannabinoids. It cites my work and others calling it, ‘The most exciting discovery in cell signaling in the past several years.’”

In other countries such as the UK and Spain, the endocannabinoid system is taught in many if not all medical schools, although surprisingly in Israel, it is not.

Could more knowledge of the ECS change cannabis scheduling?

So, whatever way you look at it, the therapeutic future of both the endocannabinoid system and the cannabis plant are defined by what is essentially outdated drug scheduling. But could a greater knowledge of the ECS allow cannabis to come out of its 50-year hinterland?

Gerdeman thinks this could be the case. “Discovering the ECS is liberating cannabis from the schedule 1 paradigm where it hasn’t really ever belonged,” he says. “And naturally it feeds into the narrative that cannabis in some shape or form could be beneficial to so many different people.”

It would follow then that as more knowledge of the endocannabinoid system seeps out of the research labs into the knowledge bank of doctors and the public at large, a change in scheduling of cannabis might just follow.

So, it’s time to go forth and publicize our neglected, biological best friend, the endocannabinoid system. Get informed, spread the word, and let’s help give the ECS the recognition it deserves.

About the Author:

Mary Biles is a British freelance writer-blogger and wandering spirit, mostly based in the Andalusian capital of Seville, Southern Spain. She is passionate about the healing potential of cannabis and is currently a guest blogger for CBD oil innovators Endoca.

 


References:

1.
Nicke D. Marijuana Your Body Makes – Endocannabinoids | The Cannapedia. The Cannapedia. http://thecannapedia.org/marijuana-your-body-makes-endocannabinoids/. Published November 5, 2016. Accessed June 18, 2017.
2.
Controlled Substances Act – Wikipedia. Wikipedia. https://en.wikipedia.org/wiki/Controlled_Substances_Act. Accessed June 18, 2017.
3.
Gregory Gerdeman. Biology | Eckerd College. https://www.eckerd.edu/biology/faculty/gerdeman/. Accessed June 18, 2017.
4.
B. Allen, M.D. D. Survey Shows Low Acceptance of the Science of the ECS (Endocannabinoid System). Outword Magazine. http://www.outwordmagazine.com/inside-outword/glbt-news/1266-survey-shows-low-acceptance-of-the-science-of-the-ecs-endocannabinoid-system. Accessed June 18, 2017.

The Benefits of Terpenes in Cannabis Essential Oil

Most of us are familiar with essential oils. You have likely enjoyed the smell of lavender, sage or eucalyptus essential oil.

Essential oils are basically the juices extracted from plants either through steam distillation, CO2 Extraction or through a press.

The main therapeutic agent in essential oils are the terpenes.

Terpenes are the life force, the quintessential 5th element or the spirit of the plant. – Ethan Russo

They are delicate, organic compounds, known as phytochemicals or metabolites.

Physiologically, Terpenes are involved in Three Crucial Processes.

  • Communication between symbiotic organisms 
  • The Attraction of Pollinating Insects
  • Plant Interactions such as creating defense mechanisms for predators. 1

Terpenes are well known for giving the plant, its unique aroma signature. These essences activate the olfactory system, which when inhaled can send messages to the limbic system of your brain, resulting in a cascading effect of positive benefits.

These fragrances may release stored memories, change your mood, calm you down in stressful times, among other physiological and physical benefits.

Dr. Ethan Russo, Neurologist and Medical Scientist, suggests that “terpenes are potent agents for animal and human behavior transformation when inhaled at ambient air level serums.”

Russo mentions that terpenes are a crucial aspect of the entourage effect that is a significant component to the therapeutic qualities of the cannabis plant.

He believes that the crucial connection between cannabinoids and terpenes is what gives cannabis its healing power, for things like: cancer, epilepsy, viral infections, depression, anxiety, and addiction.2

Terpenes are foundational components to a thriving eco-system and optimal human health.

For example, Artemisia was a sesquiterpene used to fight Malaria. Another terpene known as Yew,  has been recognized for warding off ovarian and breast cancers. Terpenes extracted from Foxglove were used in over 1 million heart disease cases. 1

Depending on which terpenes are present in each cultivar the essential oil will have a unique essence and signature.  I’ve often heard in the industry that there are over 700 cultivars of cannabis! That is some serious medicine available to the human species. That’s why you can smell sweet, earthy, skunky, pine-like, and fruity cannabis among many other essences.

Here are just a few of the main terpenes present in the blossoms of cannabis essential oil and their respective health promoting benefits.

Cannabis Essential Oil Terpene Benefits | Infographic

Cannabis Essential Oil Terpenes Infographic

In order to distinguish which terpenes are in any given essential oil, a lab analysis should be done as there are over 200 known terpenes in the cannabis plant. There are well over 19,000 terpenes in the plant kingdom.

Lastly, terpenes are volatile and vaporize at even moderate temperatures. In the middle of a hot summer day, for example, you won’t smell the aroma as much. However, in the ambrosial hours when things are cool and a dew sets over the plants the pungent terpene aromas can be better experienced making it the best time to harvest medicinal plants – such as cannabis – rich with terpenes.

Autism - boy covers ears

What’s The Answer to Autism?

In order to understand what is happening in an Autistic individual we must touch upon the critical role of the Endocannabinoid System (ECS).

A low-grade chronic infection is a primary challenge in autistic individuals – resulting in systemic inflammation. A pro-inflammatory state in both the brain and the gut are symptoms of Autism which points to a malfunctioning ECS. 

Our ECS is made up of lipids and receptors and is located in the brain, immune and nervous systems. The ECS regulates physiological systems, including appetite, pain, inflammatory response, thermoregulation, intra-ocular pressure, physical sensation, muscle control, energy balance, metabolism, sleep health, stress responses, motivation/reward, mood, and memory. 1

Autism and its relation to an imbalanced or inefficient ECS is one of the main research findings by the late great Doctor Bradstreet out of Melbourne, Florida. Stanford University research also shows us the powerful link to the ECS and Autism as well as studies put out by The American Society for Experimental NeuroTherapeutics.  2  3

Further research suggests that a gene mutation is present in autistic individuals blocking the body’s natural production of endocannabinoids. 4  This then results in behavioral challenges, issues with psychological development and imbalances in cognition.

Another key finding is that this gene mutation is what causes spastic communication instead of calm communication between pathways, this directly links to an inefficient ECS5

Take for example an Autistic person that displays an addiction to certain foods. The ECS regulates this type of impulse. An imbalanced ECS can cause irregular cravings as well as leaky gut. The ECS controls all of these physiological systems and without sufficient endocannabinoid production, it is challenging for the body to communicate properly.

Autistic individuals are also highly sensitive to environmental toxins because their system does not properly control toxins from passing through the gut lining as well as the blood-brain barrier.

This shows us a direct connection to a weak ECS. Their brain is susceptible to toxins because the ECS in the brain is malfunctioning, allowing toxins to pass the blood brain barrier causing irritation. Cannabinoids – like cannabidiol – help to seal the matrix of the brain and protect the neurovascular environment.    Because our ECS is also a part of the digestive system this same challenge happens with the gut wall; causing irritation and imbalances. It too must be sealed and cannabinoids help to accomplish this. 

With a restored and nourished ECS, a proper foundation is created leading to the healthy signaling of transmitters in the brain and gut.

The Solution:

Cannabinoids are a foundational part of a healthy and optimal functioning body.

Using extracted cannabinoids from the cannabis plant could be a therapeutic approach offered by nature. These fatty acid compounds help to:

  • Nourish the brain – ease inflammation
  • Seal the blood brain barrier from toxins, as well as
  • Heal the protein-tight-junctions in the gut so that pathogens do not get through.

With this improved state of one’s immune system, the signaling can be restored to optimal function and communication can operate in a healthy manner.

Research and real life examples show supplemental usage of cannabis oil helps to calm down these individuals and restore the ECS.

Here is an infographic sharing the importance of a well-nourished endocannabinoid system and its connection to Autism.   

*This article is dedicated to the late Dr. Jeff Bradstreet for his impeccable service to share his findings with the Autistic community.

1.
2.
Endocannabinoid Signaling in Autism. Neurotherapeutics. http://petaleconsultancy.com/Endocannabinoid-Signaling-in-Autism.pdf.
3.
Dr. Jeff B. Understanding the Endocannabinoid System and Autism and therapeutics. Youtube Presentation. https://youtu.be/s8CbIvd8p4Q.
4.
Cannabis shows great promise treating autism. Natural Society. http://naturalsociety.com/cannabis-shows-great-promise-treating-autism-symptoms/.
5.
Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain. Eurekalert. https://www.eurekalert.org/pub_releases/2013-04/cp-mfi040513.php.
group-of-happy-doctors-at-hospital

Yes, Cannabis DOES Cure Cancer

I’m sure the title of this article will anger many people, and that’s ok. Just don’t dismiss this information before you’ve read it. We will present theories, evidence, facts, and hopefully lead you to the same conclusion; that yes, Cannabis really does cure cancer.

NOTE:

This article will be updated regularly to include new research and material as well as addressing objections and questions from skeptics.

There is No Cure for Cancer…

Believing that no cure for cancer exists is based on mistaking the word cure for the word panacea.
To cure simply means “to relieve (a person or animal) of the symptoms of a disease or condition.” 1
Whereas panacea means “a solution or remedy for all difficulties or diseases.” 2

Cannabis in not a panacea. It does not work every time, for every person, on every form of cancer. And yet, that is what too many people hear when we say cannabis cures cancer.

However, cannabis has been shown to cure some forms of cancer in some people some of the time. In fact, based on our research, we are prepared to make the claim that cannabis succeeds in curing cancer more than it fails to cure cancer. Not only does it work more than 50% of the time (some people say it works 80% of the time), it is also used to reduce the negative effects of other forms of cancer treatment, and its side-effects are almost completely positive. Those treated with cannabis have almost zero incidences of reoccurring cancer, and no lasting damage or scarring from the treatment. Let’s examine some of the evidence which supports these claims.

The Facts

Here we present many scientific studies showing the effects of cannabis on cancer in a laboratory setting. We will also cross-examine these facts with genuine questions from skeptics. If we have missed an important question, feel free to leave it in the comments and we can update this article with relevant questions.

Cannabinoids kill cancer cells

 

THC Molecule

A THC Molecule

A common statement made by cannabis supporters is that cannabinoids have been shown to kill cancer cells in laboratory experiments. 3

 

Rebuttal:

So does lemon juice, so does radiation. Just because they kill cancer cells in laboratory experiments doesn’t mean they will kill cancer cells in a human in any way that is beneficial.

Response:

Remarkably, cannabinoids target cancer cells, while non-tumor cells and tissues are avoided. 4
The key is how cannabis targets and kills cancer cells:

Cannabinoids have been shown to Selectively Trigger Autophagy in Cancer Cells

Autophagy is when cells digest and recycle damaged parts of themselves.56
Reduced autophagy is found in tumor cells and may be associated with the transformation of healthy cells into malignant tumor cells,7, 8 and is thought to be a predictor of tumor growth.9
In addition, necrosis and chronic inflammation are controlled and limited by autophagy, as any damage within the cell is consumed as an energy source.10 This helps prevent damaged cells from transforming into malignant tumor cells.101112  Recent research shows autophagy’s role as a tumor suppressor.713

Cannabis has been shown to specifically target tumor cells and trigger autophagy, 141516 while simultaneously protecting nearby healthy cells.17 This means cannabis triggers cancer cells to consume themselves without harming surrounding healthy cells, and in fact, protects healthy cells.4

Cannabinoids have also been shown to Selectively Trigger Apoptosis in Tumor Cells

CBD Molecule

A CBD Molecule

Apoptosis is a kind of programmed cell death mechanism.
Abnormalities in apoptosis that lead to early cell death or the absence of normal cell death have been linked to neurodegenerative disorders and cancer,18 19 as well as cancer cell resistance to chemotherapy.20 21

An important aspect of an effective anti-tumor drug is its ability to inhibit proliferation (rapid reproduction) of cancer cells. Cancer cells proliferate rapidly in an uncontrolled manner. Also, these cells escape death mechanisms which a normal cell undergoes like apoptosis.

Cannabinoids have been shown to selectively trigger apoptosis in tumor cells. 22 23  Cannabinoids actually interact with cancer cells on a molecular level and trigger them to self-destruct.22 All this without causing any harm to surrounding healthy cells, in fact, they protect and improve the health of surrounding cells at the same time.4

They have exhibited these anti-proliferative and apoptotic effects on every form of cancer tested so far, including (but not limited to):

  • Bone cancer 22
  • Breast cancer 2223
  • Colon cancer 2324
  • Cervical cancer 25
  • Gastric cancer 26
  • Glioma (brain) cancer 2223
  • Head and neck cancer
  • Lung cancer 2223
  • Leukemia 2723
  • Lymphoma 2223
  • Oral cancer 22
  • Pancreatic cancer 22
  • Prostate cancer 22
  • Skin cancer 22
  • Thyroid carcinoma 2223

The powerful apoptotic and autophagic properties of certain cannabinoids has resulted in them being referred to as anti-tumor agents even among cancer researchers.3 The important fact to point out here is that cannabis has these anti-tumor effects without damaging any other cells in the body. Cannabis is anti-tumor while actually increasing the health of the rest of the body.4 28

 

Model of tumorigenesis

Model of tumorigenesis. The figure illustrates the formation of an invasive tumor and its metastasization to a distant organ via a blood vessel. Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Cannabinoids Shrink Tumors and Prevent Spreading (Metastasis)

According to a study published in the British journal of clinical pharmacology in 2013; “Cannabinoids possess anti-proliferative and pro-apoptotic effects and they are known to interfere with tumor neovascularization, cancer cell migration, adhesion, invasion, and metastasization.” 23

Rebuttal:

Awaiting rebuttal.

Response:

In addition to the anti-proliferative (autophagic) and pro-apoptotic effects of cannabinoids, they are also known to interfere with tumor neovascularization, cancer cell migration, adhesion, invasion, and metastasization.23

Let’s look at each of these categories in more detail.

Tumor Vascularization

Tumours can grow to a size of approximately 1–2 mm3 before requiring direct blood flow.29  Tumor Vascularization is when a tumor is able to attract the growth of blood vessels from the supportive tissue around itself. Getting sufficient blood and oxygen is critical for tumor growth.

Studies are showing that cannabinoids can drastically reduce the growth of tumors by specifically inhibiting tumor vascularization – amazingly these effects are limited to cancerous cells.30 31  So cannabinoids prevent tumors from growing by directly preventing them from attracting blood vessels to themselves, without interfering with vascularization of surrounding healthy tissue.4

 

Tumor Cell Migration and Metastasis

When tumor cells detach from their surrounding tissue and migrate to other areas of the body (metastasis), they must rely on autophagy for their energy.32

Cannabinoids have been shown to selectively switch off autophagy specifically in tumor cells that have detached and begun migrating.3233  Thus cannabinoids both encourage autophagy in tumor cells when static, and discourage autophagy in tumor cells when metastatic – showing amazing adaptability in fighting cancer.34, 3536

Overview on the functional effects of Cannabinoids on Tumor Cell Migration

CannabinoidTumor TypeRegulation of Functional EffectSignal TransductionReferences
AEABreastReduced MigrationCB1 receptorJoseph et al., 2004 33
2-AGCervicalReduced MigrationCB1 receptorRudolph et al., 2008 37
THCCervicalReduced MigrationCB1 receptorRudolph et al., 2008 37
THCColonReduced MigrationCB1 receptorJoseph et al., 2004 33
THCGlioma, AstrocytomaReduced MigrationUnknownBlázquez et al., 2008 36
CBDGliomaReduced MigrationIndependent of G-protein-coupled receptorsVaccani et al., 2005 34
THCLungReduced MigrationInhibition of EGF-induced ERK1/2, JNK, AKT; increased phosphorylation of FAKPreet et al., 2008 35

– Antitumorigenic Effects of Cannabinoids beyond Apoptosis 38

 

Cancer Cell Adhesion

Cells in our bodies have what are known as Cell Adhesion Molecules (CAM) that allow them to attach to other tissues of the body.39  The ability of cancer cells to metastasize and spread to new areas of the body relies upon these cell adhesion molecules.40 Disrupting the CAMs of tumor cells has been widely researched as an effective anti-cancer therapy.41, 42

Cannabinoids have been shown to be effective at inhibiting the adhesion and invasion of cancerous cells throughout the body.38, 43, 35  These effects are noticed only in tumor cells and does not appear to affect the CAMs of healthy cells. 4 43

Overview on the functional effects of Cannabinoids on Tumor Cell Adhesion

CANNABINOIDTUMOR TYPEFUNCTIONAL EFFECTSIGNAL TRANSDUCTIONREFERENCES
THCAstrocytomaReduced AdhesionCannabinoid receptor-independent blockade of IL-1-induced up-regulation of cell adhesion moleculesCurran et al., 2005 44
THCBreastReduced AdhesionCB1 receptor; inhibition of FAK-, and Src-phosphorylation on collagen type IVGrimaldi et al., 2006 43
THCGliomaReduced AdhesionBlockade of IL-1-induced up-regulation of cell adhesion moleculesCurran et al., 2005 44
THCNeuroblastomaReduced AdhesionCB1 receptor; up-regulation of FRNK phosphorylationZhou et al., 2002 45

– Antitumorigenic Effects of Cannabinoids beyond Apoptosis 38

Tumor Cell Invasion

Intravasation is the invasion of cancer cells through the basal membrane into a blood or lymphatic vessel. Invasion and metastasis are the greatest obstacles to successful tumor treatment.46  The greater the ability of a cancer cell to invade other membranes, the more malignant the cancer is considered.47

Cannabinoids have been shown to reduce the invasiveness of cancer cells, with some researchers even calling THC “anti-invasive” in reference to its cancer fighting ability. 48, 49, 50  Cannabinoids may therefore offer a therapeutic option in the treatment of highly invasive cancers without risk of damaging healthy cells.4 48

Overview on the functional effects of Cannabinoids on Tumor Cell Invasion

CANNABINOIDTUMOR TYPEFUNCTIONAL EFFECTSIGNAL TRANSDUCTIONREFERENCES
CBDBreastReduced InvasionId-1 down-regulationMcAllister et al., 2007 51
THCCervicalReduced InvasionCB1, CB2 receptors; TIMP-1 up-regulationRamer & Hinz, 2008 48
THCLungReduced InvasionCB1, CB2 receptors; TIMP-1 up-regulationRamer & Hinz, 2008 48
THCLungReduced InvasionInhibition of EGF-induced ERK1/2, JNK, AKT; increased phosphorylation of FAKPreet et al., 2008 35
2-AGProstateReduced InvasionCB1Nithipatakom et al., 2004 50

– Antitumorigenic Effects of Cannabinoids beyond Apoptosis 38

Tumor Metastases

Tumor cell migration, adhesion, and invasion are all parts of the progression of metastases. Collectively, cannabinoids reduce the expansion of tumor cells in several ways that are not yet fully understood. What is clear is that cannabinoids are antimetastatic – and cannabinoids prevent the spread of cancer in addition to killing cancer cells.38

Overview on the functional effects of Cannabinoids on Tumor Cell Metastasization

CANNABINOIDTUMOR TYPEFUNCTIONAL EFFECTSIGNAL TRANSDUCTIONREFERENCES
CBDBreastReduced MetastasesCa2+, ROSLigresti et al., 2006 52
AEABreastReduced MetastasesCB1 receptorGrimaldi et al., 2006 43
THCBreastDecreased Cell ProliferationUnknownSchlumpf et al., 2008 53
AEALungReduced MetastasesCB1 receptorPortella et al., 2003 54
THCLungReduced Metastasesnhibition of FAK-, ERK1/2- and Akt-phosphorylationPreet et al., 2008 35
THCSkin CancerReduced MetastasesInhibition of the Akt signal transduction pathwayBlázquez et al., 2006 55

 

Conclusion:

When an oncologist attempts to target a cancerous growth for treatment, they must understand what type of cancer it is, what stage it is in, where it is in the body, and more. One treatment that kills certain types of tumor cells may increase the growth and spread of other types of tumor cells. This is why oncology is such a difficult science.

The research presented here indicates that the cannabis plant contains compounds (cannabinoids) that can fight (apoptosis), prevent (autophagy), and even reverse (triggered autophagy) most types of tumor cells in addition to preventing the spread of cancer throughout the body (cancer cell migration, metastasization). All of this is achieved while causing no harm to healthy cells.4 28

It’s almost as if our body knows how to heal itself, and cannabis gives our body the tools it needs to heal itself of cancer.

The witnesses we present next will provide evidence that consuming the cannabis plant in a concentrated oil form delivers many different cannabinoids to the body. When given these cannabinoids in their natural form, they appear to help the body fight, prevent, and reverse cancer without the direction of an oncologist or any other specialist. We propose, based on this evidence, that cannabis simply helps increase the body’s natural defenses against all forms of cancer.

The Witnesses

Here we present testimony from several people who claim to have cured their cancer using cannabis oil. We will also cross-examine these witnesses with genuine questions from skeptics.

Sharon Kelly

Sharon Kelly poses with her scans before and after using cannabis oil

Sharon Kelly poses with her scans before and after using cannabis oil

54-year-old Sharon Kelly was diagnosed with non-small-cell lung cancer. She was told that the cancer in her body had made its way to her lymph nodes and the lining of her stomach; and that she could expect to survive for somewhere between six and nine months.

She was informed that radiation and chemo-therapy were not valid treatment options for a patient with stage four lung cancer, as they would likely only make her sicker. Instead, they urged her to return home to husband and children to enjoy her remaining 9 months of life.

Without adequate help from the medical community, Kelly’s youngest daughter turned to the internet and began reading numerous testimonials from cancer patients who had found relief with cannabis oil. With nothing left to lose, Kelly decided to try it for herself and began taking a small dose orally several times a day.

After noting how tired she became after taking the oil orally, she began researching cannabis suppositories, or drug-administration systems that are inserted into the rectum, vagina or urethra. She found that this method didn’t make her tired, and that it allowed her to take the full recommended dose without complication.

She eventually upped her dosage to two grams per day, and paired the treatment with an alkalizing, clean-eating diet. Within a few months, her tumor had shrunk from 5cm to 2.1cm and her lymph nodes had retained their normal size. Her doctors noted the fluid surrounding her heart was also no longer visible.

After seven months of cannabis oil treatment, Kelly’s scans indicated she was completely cancer-free, shocking her oncologist and others familiar with her case. Now, 13 months after her initial diagnosis, Kelly remains cancer-free, and credits the use of cannabis oil for not only her otherwise unexplained recovery, but also her ability to live out the rest of her life amidst the love and comfort of her family.56

Corrie Yelland

Corrie Yelland in 2012In July of 2011, Corrie Yelland was diagnosed with Anal Canal Cancer (the same form of cancer that took Farrah Fawcett’s life). Following 2 surgeries, her cancer still remained. The only option offered was to endure a regime of radiation treatments.

The Anal Canal is considered “the worst area of the body to radiate.” The radiation beam will hit both the coccyx and pubic bone; potentially causing permanent damage.

Corrie was told she would suffer 2nd and 3rd degree burns vaginally, rectally, across her buttocks, as well as her entire “nether regions.” Additionally, there was a “good possibility” both her vagina and rectum would fuse shut from the burns and subsequent scarring.

Corrie told her doctor that she needed time to think it over before agreeing to the procedure. However, without treatment she was given only 2-4 months, possibly 6 months to live.

One day, Corrie was given a copy of Run From The Cure – by Rick Simpson. She describes what happened next:

“Here was this man, a seemingly super straight small town Nova Scotian, talking about these amazing results he had seen with in himself and other people taking Cannabis and curing themselves of a myriad of diseases including end stage cancers.
After hearing what Rick had to say, and watching the testimonials in the video, I was feeling some hope for the first time. For 2 weeks I did nothing but research cannabis as a medicine. I was stunned by the sheer number of studies on Pub Med indicating that cannabis indeed has the capacity to heal. I started using cannabis 2 months ago as per Rick Simpson’s protocol from his video. (He recommends starting out small, and slowly upping the dose so ones’ body becomes accustomed to it, without being high constantly. As a person who hasn’t smoked pot since my late teens, early 20’s, the non-high aspect appealed to me). I had huge hopes to cure my cancer, and embarked on my fight to live.”

She also began filling gelatin capsules with a mixture of the cannabis oil and olive oil and inserting them rectally. 2 weeks into the cannabis oil regime, Corrie noticed most of her pain was gone. Typically needing 10-15 Tylenol per day, she was down to just 1/2 a tablet per day.

On September 20, 2012, she returned to her surgeon. He examined her a total of 3 times just to make sure of the results. Finally his prognosis:

“It’s gone! I can’t find anything at all. If it wasn’t for the scar tissue I would never have known you had ever had cancer.”

No doctor, no radiation or chemotherapy, and Corrie had successfully cured her cancer with cannabis oil. 57

Here is Corrie’s official medical documentation:

The Verdict

If any of the information presented in this article is inaccurate, please contact us with corrections. If new information is discovered, please contact us with that information. However, until such new evidence is presented to us, we confidently declare:

Yes, Cannabis Does Cure Cancer.

Science is not just for “scientists” to do in a laboratory. Science is the only way to establish something as true or false, and experiments can be done in a lab or on a kitchen table. We have taken you through the scientific method in this article:

  1. We proposed a Hypothesis.
  2. We then tested this hypothesis by examining known facts and interviewing witnesses.
  3. Finally, it comes down to you to analyze whether the evidence supports our hypothesis or not.

Don’t let anyone tell you what is true or false, especially when your health or your life might depend upon it. Test their statement, analyze the evidence, and then decide for yourself.

If you enjoyed this article, please leave us a comment below (way below – there’s a LOT of references). Also, please share this information with anyone who might find it interesting.

Right now, cannabis is not legal for Millions of people to access. And those who can access it may not have access to reliable sources. The only way to change all of that is to spread accurate information about this plant. Educate yourself first, and then help us to educate others!

 

Thank you for your time and attention.
Sincerely,
DJ Nicke

 


References:

1.
cure – definition of cure in English | Oxford Dictionaries. Oxford Dictionaries | English. https://en.oxforddictionaries.com/definition/cure. Accessed December 17, 2016.
2.
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Old man suffers heart attack with grandson

What Everyone Must Know About Cannabis and Heart Disease

Increasing evidence is showing that CBD from the Cannabis plant is beneficial for cardiovascular conditions such as atherosclerosis and heart disease. Most testing has been done on cannabidiol (CBD) and THC, yet other cannabinoids such as Anandamide have also been found to have positive effects on heart conditions.

Heart disease is the leading cause of death in the United States, taking an estimated 788,000 lives per year in 2011.  Cardiovascular diseases take out more lives than all cancers combined.1 

Relaxing Arterial Walls

One of the main findings is how CBD helps to relax arterial walls, lessening tension in the blood vessels. 2 While it relaxes it also protects the arteries from inflammation.3  CBD is a natural way to reduce the metabolic issues of high glucose responses present in heart disease patients as well as diabetes, decreasing vein wall permeability.4

Reducing Inflammation

In heart disease and cardiovascular conditions, there is too much inflammation. New lab tests show the immune modulating and anti-inflammatory components of cannabinoids, coupled with the anti-oxidant effects, protect the heart specifically when tissue damage is present from lack of oxygen and blood supply. 

It also protects the heart from cardiomyopathy – a disease of the heart muscles causing hardening and thickening and lack of blood flow. 2 A very interesting finding was that CBD stopped endotoxin production.  These types of pro-inflammatory cytokines are exactly what cause heart conditions to progress; so inhibiting endotoxin production is a profound key to heart disease and other cardiovascular conditions. 5

Reducing Arterial Plaque

Arterial Plaque is a huge factor in heart disease, atherosclerosis, and cardiovascular issues. When this plaque builds up throughout the arterial walls it makes it very challenging for the heart to pump blood. 

CBD also decreased the adhesion of plaque to arterial walls. This is a key finding, as this type of plaque build-up is one of the main causes of the progression of heart disease. 

The Research Is In…

Research and studies are showing a direct link between treating or even preventing health challenges like atherosclerosis – and the endocannabinoid system.  A study was conducted utilizing tetrahydrocannabinol (or THC) on mice. It was evident that THC activated the CB2 receptors, which inhibited plaque formation within the arteries of the mice. Lab testing further revealed that low oral doses of THC, at about 1mg per day, resulted in the plaque build-up within the arteries halting its progression.6

We are seeing more and more studies suggest that our endocannabinoid system plays a large role in our body’s defense against cardiovascular diseases. 

In summary, CBD has the ability to calm inflammation in the vascular system, relax the arterial walls and work as an immune modulator and anti-oxidant while decreasing the amount of plaque build up in the walls of the arteries. These findings suggest yet another potent use for cannabinoids and cannabis.

Find out what forms of cannabis are legal where you live, and fight for the legalization of those that are not. Your life, or the life of someone you love, could very well be saved by this plant one day.

1.
Heart Disease: Scope and Impact. theheartfoundation.org. http://www.theheartfoundation.org/heart-disease-facts/heart-disease-statistics/.
2.
Is the cardiovascular system a therapeutic target for cannabidiol? NCBI. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579247/.
3.
Is the cardiovascular system a therapeutic target for cannabidiol? NCBI . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579247/.
4.
The potential use of cannabidiol in the therapy of metabolic syndrome. akademiai. http://www.akademiai.com/doi/abs/10.1556/OH.2012.29308.
5.
Role of bacterial endotoxin in chronic heart failure: the gut of the matter. Pub Med. https://www.ncbi.nlm.nih.gov/pubmed/17510602.
6.
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature. http://www.nature.com/nature/journal/v434/n7034/abs/nature03389.html.

Cracking the Cannabis Epilepsy Code

Epilepsy is a central nervous system and neurological disorder characterized by seizures, convulsions, and involuntary movements.1 The use of cannabis for epilepsy is nothing new. In fact, the first documented use of the hemp plant for this purpose was in 1,800 B.C.E in Ancient Sumer (modern day Southern Iraq). In these times neurologists would use Indian hemp to successfully control seizures amongst their patients.2

Seizures are initiated by brain cells that get overexcited and fire in an abnormal fashion.

One of the most interesting findings on cannabis and its therapeutic properties is how it activates retrograde signaling in the brain. Retrograde simply means moving backward. This reverse signaling process, unique to cannabinoids controls the output of neurons that fire and quiets down the over-excited neurons that cause convulsions and seizures.

Key Point: When a neuron is overstimulated, such as with epilepsy, having the ability to send a signal backwards to the signaling neuron is important to control and calm down the neurons. This is achieved through the use of cannabinoids as neurotransmitters.

As we now know CB1 receptors reside primarily on the nerve cells in the brain and spinal cord.3 Research shows that during a seizure, our endocannabinoid system becomes activated, especially the CB1 receptor proteins.45

The cannabis plant offers over 100 phytocannabinoids and an array of terpenoids that actually create what is known as the “entourage effect” (coined by S. Ben- Shabat in 1998) and can help supply the receptors with these crucial compounds.

The dosage of cannabis oil for epilepsy is patient specific. The mayo clinic suggests the following dosage for epilepsy (2014): “To treat epilepsy, 200-300 milligrams of CBD has been taken by mouth daily for up to 4.5 months.”

Dr. Geddy owner and founder of Gedde Whole Health, shares, “Some children are so sensitized to medications that they need to start at a very low dose, and give it plenty of time to work.”

Other clinical trials report that cannabinoids created an internal domino effect in the cell network, producing adaptive like capabilities to handle the seizures more effectively.

Some of the main benefits of cannabinoids for epilepsy include:

  • Mood Regulation
  • Enhancement of cognitive function
  • Anti-oxidant effects to protect the brain
  • Anti-inflammatory agent
  • Energy balance
  • Reduce pro-inflammatory cytokines

Through retrograde signaling, the endogenous cannabinoid system provides on demand protection against seizures and the cannabinoids from cannabis oil help to modulate the communication between each pathway.

There is no doubt epilepsy is influenced by the endocannabinoid system and the entourage effects of cannabis oil shows to be a promising remedy for this type of disease.

I would like to add that the US Government holds patents on Cannabis as a neuroprotectant. Perhaps consider this information when making an educated decision on the use of cannabis oil for neurological disorders. Up until now, a lot of funding has gone to finding ways to demonize the plant and so it is up to us to uncover the research on our own, honoring the antiquity and historical use of cannabis among medical doctors.

1.
Definition of EPILEPSY. Merriam-Webster. http://www.merriam-webster.com/dictionary/epilepsy. Accessed November 27, 2016.
2.
Cannabinoids in the Treatment of Epilepsy. The New England Journal of Medicine. http://www.nejm.org/doi/pdf/10.1056/NEJMra1407304. Published September 10, 2015. Accessed November 27, 2016.
3.
Robertson S. Cannabinoid Receptors. News-Medical.net. http://www.news-medical.net/health/Cannabinoid-Receptors.aspx. Published June 2, 2010. Accessed November 27, 2016.
4.
Cannabinoids: Defending the Epileptic Brain. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176332/. Published May 4, 2004. Accessed November 27, 2016.
5.
Cannabinoids and Epilepsy. Neurotherapeutics. http://cannabisclinicians.org/wp-content/uploads/2015/11/Cannabinoids-and-Epilpsy.pdf. Published 2015. Accessed November 27, 2016.

Could Cannabis Shrink Tumors?

Tumors or neoplasms are abnormal growths of tissue or what is known as a mass of abnormal cells. Generally, there are three types of tumors: benign, pre-malignant and malignant.

A benign tumor is a non-cancerous growth.  Although these types of tumors do not spread into other areas they can cause pressure onto surrounding blood vessels and nerves.

A pre-malignant tumor is compromised of disordered cells that have the risk of turning into cancer.

And there is a malignant tumor which is a cancerous tumor that spreads to other areas of the body, which can be life-threatening if not resolved.

What new evidence are we seeing when it comes to cannabinoids role in shrinking tumors?

Lab results are showing that cannabinoids help stop new blood vessels from feeding tumors. This is very important, because the more blood flow to a tumor, the more it will grow. With less blood flow, the tumor will likely shrink and ultimately dissolve.1

Research is also showing us that cannabinoids inhibit the proliferation of cancerous cells spreading to other areas of the body, a process known as metastasis where a secondary growth forms. Certain cannabinoids are helpful in keeping things in a tight area instead of allowing healthy cells to get bombarded with diseased tissue.2

When the body is under stress it can benefit from assistance to go in and clean up the cells. With the use of cannabinoids,the body’s ability to promote cleansing of diseased cells is enhanced. Think of It like having a garbage disposal instead of a trash can. This method of waste clean up is more efficient.3

Through animal lab testing, we are seeing the ability of certain cannabinoids to inhibit the growth of metastasis especially in breast, brain and lung cancer growths, resulting in autophagy.1

What is happening is that certain cannabinoids are downregulating the expression of unhealthy genes, specifically ID-1 genes in order to restrain tumor growth2

The main cannabinoids that were researched in this particular study were:

Cannabidiol
JWH-015
Win55,212-2
JWH-133

With the down-regulation of unhealthy genes and up-regulation of autophagy (our ability to digest unhealthy cells), the body starts to regain homeostasis. When you activate this biological process, it assists you to repair naturally. Three key benefits to autophagy are:

  1. Decrease Inflammation
  2. Maximize your Biological Processes and Turn on Healthy Genes
  3. Reduce the Speed of the Aging Process

The findings suggest that cannabinoids found in the cannabis plant can function as a direct approach to tumor suppression and could help first line therapies (such as pharmaceuticals) to create improved results.123

References:

1.
Cannabis, cannabinoids and cancer – the evidence so far. Cancer Research UK – Science blog. http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/. Published July 25, 2012. Accessed November 18, 2016.
2.
The antitumor activity of plant-derived non-psychoactive cannabinoids. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470774/. Published April 28, 2015. Accessed November 18, 2016.
3.
Autophagy—How Your Body Detoxifies and Repairs Itself. Mercola.com. http://fitness.mercola.com/sites/fitness/archive/2016/03/11/autophagy.aspx. Published March 11, 2016. Accessed November 18, 2016.

Could Cannabidiol from Cannabis Kill Breast Cancer Cells?

This article shares sound evidence that Cannabidiol from Cannabis could be a potent player in the reversal of Breast Cancer.

A powerful new discovery is shedding light on a subject that all too often leaves many in the dark, and often fearful in this world.

To put things into perspective breast cancer is the second leading cause of cancer-related deaths in women in The United States. (http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-key-statistics)

Cannabidiol is a therapeutic and non-psychoactive constituent of the Cannabis Sativa plant. It is a key phytocannabinoid (phyto meaning it is plant derived), making up roughly 40% of the cannabis plant’s cannabinoid structure.

We continue to see more and more solid evidence that this cannabinoid plays an active role in reversing and/or preventing breast cancer.

How Could a Plant Prevent Cancer?

Did you know your body has an endocannabinoid system (endo meaning it is naturally occurring within your body)? Within your endocannabinoid system is a group of endogenous cannabinoid receptors; located in the brain and throughout the central and peripheral nervous systems.

CB1 receptors are found in the brain and nervous system while CB2 receptors are mainly found in the body’s immune system.

The phytocannabinoids found in Cannabis fit like lock and key into the brain and body assisting communication between pathways.

When cannabinoids bind with CB2 receptors, they work as immune modulators. They are able to prevent and reduce inflammation (by interrupting the pro-inflammatory cytokine pathway), and are crucial players in removing diseased cells from the body.  

Cannabidiol also shows evidence of being anti-neoplastic – which means it prevents and/or inhibits tumor growth.

An article from the American Association of Cancer Research (noted in the resources section below) suggests that Cytochrome C is a key player in the electron transport to our mitochondria, which provides energy to our bodies. Without this free flow of energy, healthy cells cannot thrive and override the malaise of the disease.

Cytochrome C by definition is a vital component to providing the mitochondria of our cells with energy. If the message is not relayed then disfunction of the cell results.

Furthermore, Cytochrome C assists the apoptosis of breast cancer cells which is of paramount importance to reversing this weakening condition.

The main thing to understand is that our cell mitochondria play a crucial role in warding off cancer cells and DNA mutation. When the mitochondria produce less ATP, the result is often damaged mitochondria. ATP (Adenosine triphosphate) is a way for cells to store and utilize energy.

How could one increase Cytochrome C in an effort to enhance ATP in the mitochondria? The intake of Cannabinoids such as Cannabidiol and other cannabinoids found in Cannabis looks to be a promising way to increase Cytochrome activity in the human body.

Other adjuncts to this would be therapies such as low lever laser therapy. Red light and infrared wavelengths have the ability to penetrate the skin and support cell regeneration. These lasers have been shown to increase cytochrome c and free up energy enhancing cell repair.

By doing our own due diligence and learning how the body works to communicate through its very own endocannabinoid system we can take action and release the fear around this subject, but instead empower one another to true health and well-being.

Resources:

http://mct.aacrjournals.org/content/10/7/1161

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075374/

http://reset.me/study/study-cannabidiol-cbd-kills-breast-cancer-cells/