ADD/ADHD Could Be A Cannabinoid Deficiency

ADD/ADHD or attention deficit disorder and attention hyperactivity disorder is known as a chronic condition resulting in impulsive behaviors, lack of focus and challenges with sustaining one’s attention.1

What is occurring in someone’s neurological system that is challenged with ADD/ADHD?

Scientists are finding that a dopamine shortage could be one of the main problems in these chronic conditions. Dopamine is a chemical neurotransmitter associated with our attention, memory and cognitive function.

Someone with ADD often has information overload. Essentially, too much information is flooding into the receptors of the brain causing confusion. When the system overloads, over and over impulsive behavioral patterns result.

The common drug of choice for ADD/ADHD has been Ritalin which was approved by the Federal Drug Administration in 1955.

Things like Adderall and Ritalin work to increase dopamine shortages, yet come at a serious expense to your body. In fact, so much so, that The Food and Drug Administration (FDA) requires a “black box” warning on all methylphenidate drugs, including Ritalin.2 Medical studies have proven Ritalin carries an enhanced risk of serious, or even life-threatening effects.

Research is showing that there are other more natural approaches to healing ADD/ADHD.

Dr. Bearman, a figurehead of Cannabis Research out of California shares that, “Cannabis appears to treat ADD and ADHD by increasing the availability of dopamine.”3 Therapeutic doses of cannabinoids could ultimately correct the dopamine deficiency so many ADD/ADHD patients suffer with. In fact, Dr. Bearman has seen much success with his own patients, utilizing proper dosages of cannabis.

Dr. Bearman goes on to share that what we are really seeing is what is known as an endocannabinoid deficiency.

This could suggest our inherent cannabinoid system is simply lacking in vital nourishment from cannabinoids so the neurotransmitters cannot fire effectively. We are becoming increasingly aware that the brain function is interrelated to our endogenous cannabinoid system and with time more studies will help to validate these findings.

Another major connection to ADD/ADHD is the health of our gut microbiome.

Because the gut acts as our second brain this is fundamental in solving ADD/ADHD. Increasing studies suggest that the if the tight junctions of the gut are not well sealed we notice a condition called leaky gut. In fact 75% of people with ADD have a leaky gut.4

A study conducted in 2011 by the British Journal of Pharmacology found that Phytocannabinoids from cannabis (specifically THC and Cannabidiol) have been shown to decrease the intestinal permeability of the gut wall, while simultaneously increasing the tight junction proteins of the gut, specifically protein claudin-1.5

This particular protein is vital in cell to cell adhesion which helps keep the gut lining strong which ensures proper communication with your brain. This indeed is a very crucial aspect to a healthy focused individual as the gut is now known as the second brain. Nourishing the body with cannabinoid rich plants could be a natural approach to solving the ADD/ADHD condition.

1.
The History of ADHD: A Timeline. Healthline. http://www.healthline.com/health/adhd/history#Overview1. Published February 26, 2015. Accessed November 15, 2016.
2.
Ritalin (methylphenidate) Side Effects and Warnings. Drug Enquirer. http://ritalinsideeffects.net/. Accessed November 15, 2016.
3.
Is Cannabis Good For ADHD? Leaf Science. http://www.leafscience.com/2016/01/22/cannabis-good-adhd/. Published January 22, 2016. Accessed November 15, 2016.
4.
Linking ADHD to a Leaky gut? Naturopathetarian. http://naturopathetarian.com/linking-adhd-to-a-leaky-gut/. Published November 15, 2015. Accessed November 15, 2016.
5.
Leaky Gut Syndrome: Cannabinoids and the Endocannabinoid System (ECS) as a therapeutic target. SC Labs. http://sclabs.com/about-blog/item/131-leaky-gut-syndrome-cannabinoids-and-the-endocannabinoid-system-ecs-as-a-therapeutic-target.html. Published November 12, 2014. Accessed November 15, 2016.

The Business of Cannabis

I’m going to talk to you about getting into some aspect of the Business of Cannabis, but first a little about why me: I’ve been pioneering new products and new segments in the soyfoods industry for 36 years, and hemp food for 22 years.

I sold tofu in the Reagan ‘80s 1, which made it easy to sell hemp foods in the go-go ‘90s. I was first-mover by years in what today is more than 90% of the Canadian hemp industry – and provided the first business model. I was on the Inc 500 list of fastest-growing companies in 1993 2 – and introduced more than 150 products to the market. I literally wrote the book on hempseed foods 3, twice 4, and spoke to 3 million viewers about hemp foods on the Roseanne Show (afternoon talk show) on CBS in 1999 5 .

After spending $2.5 million and 8 years developing a branded 22-member global hemp food supply network selling over a dozen hemp foods internationally, I walked away from it and retired in 2002 when a hemp fiber group killed the food market for years by suing DEA over food against my wishes. 6

Ten years ago I moved to Colorado, where I researched and documented the emerging CBD hemp industry. I started and run both the Hemp Food Association, started in 1998, and the Medicinal Hemp Association to advocate and educate on CBD. I’ve been advocating for Cannabis reform since 1972 and California’s first Proposition 19, to legalize.

I’m 60 years old now, and after spending the last 44 years studying and advocating Cannabis, I have to say that today is an incredibly exciting time to be alive if you are a friend of her. Just this week 7 more US states legalized, bringing to 45 (90% of the 50) states which have some form of Cannabis legalization 7 , including the population centers of California, New York, New Jersey, and Illinois. And President Obama said just last week that federal prohibition was “untenable.” 8

Notwithstanding the fact that Trump was elected President, things are about to change and change fast in the US, which means big changes for other nations will also move faster. The business of Cannabis is massive in its volume, turnover, scale, technology, potential, and most importantly, its relevance to healing, health, and well-being. 100% of the human and pet population can benefit from Cannabinoids. 9  If you are a young person looking for a career or profession, few other industries will offer you the security, creativity, upside potential, or fun.

While you may at first consider working with another Cannabis company to gain experience (even Master Growers make $120,000 10 ), I am here to tell you that perhaps the best thing you can do for yourself is starting your own business. In America, we use a French term for that: Entrepreneurship. Your own company gives you far more freedom from bosses, creative expression, the potential to make millions, and daily fun.

What is a “Cannabis Business”?

First, let’s define what is a “Cannabis business:” although the British have popularized the word “Cannabis” to mean what Americans call “marijuana,” in fact the genus Cannabis includes hemp, long marijuana’s red-haired stepchild11 . Few understand that while marijuana is basically only good for producing Cannabinoids and Terpenes (hallelujah!), hemp also does that, and so much more:

  • superfoods like protein and omega-3
  • sprouts
  • Cannflavins
  • Cannabisin
  • CBD
  • CBG
  • terpenes
  • building materials
  • clothes
  • textiles
  • diesel
  • alcohol
  • ethanol
  • carbon fiber
  • graphene supercapacitors
  • paper
  • culinary oil
  • and much more.

Hemp may disrupt entire old school industries, which is why recreational marijuana is more legal to grow than hemp in 7 states , and strangled by “research-only by universities” regulations.12

What Kinds of Businesses are Possible with Cannabis?

In Colorado, hemp and marijuana legalization brought about 18,000 new jobs in a state of 5 million. 13 Innovations such as 26% CBD hemp, 5% terpene marijuana, the first buildings made from hemp in the country, hundreds of millions of dollars from new taxes and new millionaires. The first CBD dabs, terpene dabs, fractional distillation, terpene as a solvent, sprouting, juicing, CBN production. Hemp (0.3% max THC) bred, grown, cured, extracted, and smoked like marijuana for the first time (for CBD). That’s the leading edge, and if you are looking for a new business to start, be sure to look to Colorado. In fact, I suggest you find best practices companies everywhere and emulate them. Borrow their best ideas for your new business.

I started an Inc 500 fastest-growing international food company with $400 and a spare bedroom and sold it 15 years later for almost $4 million.14 If I can do it, SO CAN YOU. Not all new businesses require tons of start-up capital. Consider leasing your equipment. Factoring your receivables. Get long payment terms from your suppliers but cash terms from your customers. Hit up your rich uncle to be an angel investor. Think outside the box, practice guerilla marketing.

Don’t waste your precious start-up capital on University, start a business instead (this coming from a guy with 2 degrees in marketing). Learn EVERYTHING you can about your chosen craft, but also marketing and finance because you are going to need it, big time.

The art in your business will often be developing workarounds for dealing with regulations, lack of financing, banking, and marketing. Expect push-back from friends, relatives, and the government, be polite but firm when confronted with insults to your vision.

Get up early and work late, because your competitors are. Maintain integrity, but don’t be a push-over. Milk the positive Public Relations aspect of what you are doing, that’s free advertising (use non-profit trade associations as a PR division of your company, the others do).

Give back to your community, just on principle. Always remember what drives you to do this, whether your customers, patients, children, or whatever.

Create entire new industries and product segments, and when you do, totally own them as long as possible. Protect IP ruthlessly, it might be worth a ton later on. Competitors are not your “Bro,” no matter how many times they call you that. Be more Pro than Bro.

How Big Is The Cannabis Market?

Every estimate on the size of the Cannabis industry is understated, some by an order of magnitude or more. Those are all based on how Cannabis will impact EXISTING industries and companies. On that they may be right: for instance, I expect at least 15% of pharmaceuticals will be disrupted by Cannabinoid medicines.15 However, those estimates don’t include the entire new industries and industry segments that will be created, like I did with “Hemp Nut” shelled hempseed in North America 20 years ago. It is very likely that the overall Cannabis industry in 20 years will be in the many Trillions of dollars, that’s thousands of billions of dollars.16

So What is Possible For You to do as a New Business?

The obvious ones of course: growing flowers and extracting (it’s not all about THC any longer; with 144 Cannabinoids and 120 Terpenes, the range of possible blends is over 14,000). Dabs, shatter, wax, crumble, oils, tinctures, capsules, nanoparticles, Nobacco and Not-Pot CBD flowers and dabs, vape drippers and cartridges, 17 inhalers, eye drops, skin sprays, nasal sprays, transdermal patches, chewing gum, isolates, edibles (the THC “medibles” market in just Colorado is larger than all edible hemp products imported from Canada 18 ), and more. All those could either be THC products, the somewhat more legal CBD, or whatever.

Then there’s the seed: shelled or pressed for oil, with the very high-quality protein and omega-3 in the nut you can make medical and nutritional drinks like Ensure, an energy blast like 5-hour energy shot, medical and special-diet foods, or functional foods. Extract cancer-fighting Cannabisin from the shells.19 Sprouts taste great and contain CBG and Cannaflavins. From the nut make burgers, breads, milk, cheese, yogurt, drinks, bars, bake mixes, cookies, ice cream, and more. Perhaps even with 25 mg of CBD per serving. Seed, sprouts, and fresh or dried tops can be powdered without heat. Juice fresh tops like wheatgrass. Seed oil can be used in cosmetics or cooking – and is high in omega-3 and GLA. Or in body care products, like lotions. It can even be used to make a hot oil hair pack, soap or diesel fuel.

Use Cannabis essential oil for its medicinal properties, or to scent a perfume or room freshener. It can also be used as a flavoring for candies and energy drinks to taste like a grow room in flower.

On the fiber side, you could do clothes, woven and nonwoven textiles, cordage, even replace fiberglass insulation with hempcrete. Someday your car and home may be powered by hemp: graphene supercapacitors made from hemp fiber are cheaper and perform better.20 Single-atom-thick carbon-fiber from hemp is totally possible, too.21 Ethanol and moonshine can be made from the stalk, which can be petrified to be harder than drumsticks. Plastics can be made with hemp22 , also paper and cardboard boxes, toilet paper. Zeoform furniture, and surfboards. Cars even contain hemp fiber in the interior panels and for sound-deadening.23 Then there’s phytoremediation, healing contaminated soil,24 as well as breaking up compacted soil, as a rotation crop, or stabilizing erosion.

Consider the ancillary industries: open an analytical lab, or a clinic for patients, or produce clones, or breed and multiply new cultivars.

Or in finance: do credit card processing, or lease equipment, perhaps a roll-up of a handful of Cannabis businesses, go public and float stock. If you have experience in other industries, pivot to Cannabis. The world of Cannabis is huge, and getting bigger by the day. Be part of it, it needs you and your talents, vision and good energy.

What About Prohibition?

If you live in a state or country with Prohibition and are afraid of trouble, know this: the most repressive laws and cruelest law enforcement on the planet couldn’t even make a tiny dent in the Cannabis industry in the US. As of now, 45 of the 50 states, 90%, have listened to a majority of the people and legalized some form of Cannabis.7 If it can happen there under very difficult conditions, it can happen anywhere. Including your country too, but you can’t wait for someone else to do it. You have to be the change you want to see. Write letters, make phone calls, see your politicians face-to-face, make them feel safe legalizing, that the people are on their side. Build coalitions with others, get active. If the laws can change in the US, they can change where you live too. Make it so.

In the meantime, do a Canna-business that won’t get you in trouble. Publish a magazine, write a book, educate in town halls, teach your friends and neighbors. Change is in the air, everywhere. Not only the US; the Police Union in Italy recently came out for legalization. There will very soon be a tipping point at which time massive change will happen fast. Like with the Hundredth Monkey phenomenon, YOU be the 100th monkey. You owe it to yourself, your brethren, and the world.
– Richard Rose
11/11/16
Cannafest, Prague

References:

1.
Stewart C. Santa Rosa Man Sells Food Derived from the Plant. San Francisco Chronicle. http://www.sfgate.com/bayarea/article/Hemp-Hemp-Hooray-Santa-Rosa-man-sells-food-2949011.php. Published February 23, 2001. Accessed November 18, 2016.
2.
Sharon’s Finest (281) – America’s Fastest-Growing Private Companies. Inc.com. http://www.inc.com/magazine/19931001/6089.html. Published September 30, 1993. Accessed November 18, 2016.
3.
Rose R, Mars B. The Hemp Nut Health and Cookbook. HempNut Inc.; 2000.
4.
Rose R, Mars B. The Hempnut Cookbook. Book Publishing Company (TN); 2004.
5.
Barr R. Roseanne and Richard Make HempNut Potato Salad (1999). YouTube. https://www.youtube.com/watch?v=PxnJxrWg9ys&t=36s. Published December 29, 2015. Accessed November 18, 2016. [Source]
6.
Information: Legal Cases: DEA Hemp Food Rules. Vote Hemp. http://www.votehemp.com/legal_cases_DEA.html. Accessed November 18, 2016.
7.
State Marijuana Laws in 2016 Map. Governing. http://www.governing.com/gov-data/state-marijuana-laws-map-medical-recreational.html. Accessed November 18, 2016.
8.
Maher B. President Obama: FULL INTERVIEW | Real Time with Bill Maher (HBO). YouTube. https://www.youtube.com/watch?v=xXH5agV7skw. Published November 4, 2016. Accessed November 18, 2016. [Source]
9.
Endocannabinoid system. Wikipedia. https://en.wikipedia.org/wiki/Endocannabinoid_system. Accessed November 18, 2016.
10.
Master Grower. THC JOBS. https://www.thcjobs.com/job/master-grower-9/. Published July 7, 2015. Accessed November 18, 2016.
11.
Cannabis. Wikipedia. https://en.wikipedia.org/wiki/Cannabis. Accessed November 18, 2016.
12.
Marijuana research will remain restricted with DEA decision. STAT. https://www.statnews.com/2016/08/10/marijuana-medical-research-dea/. Published August 11, 2016. Accessed November 18, 2016.
13.
Ingraham C. The marijuana industry created more than 18,000 new jobs in Colorado last year. The Washington Post. https://www.washingtonpost.com/news/wonk/wp/2016/10/27/the-marijuana-industry-created-over-18000-new-jobs-in-colorado-last-year/. Published October 27, 2016. Accessed November 18, 2016.
14.
Times SA. Tree of Life acquires soy cheese company. St. Augustine Times. http://staugustine.com/stories/042501/bus_0425010039.shtml#.WC8b6hIrISQ. Published April 25, 2001. Accessed November 18, 2016.
15.
ASX Company to Disrupt $916BN Big Pharma Industry? The Next Biotech. http://www.nextbiotech.com.au/asx-company-to-disrupt-916bn-big-pharma-industry/. Published July 20, 2015. Accessed November 21, 2016.
16.
L. Is Cannabis the World’s Next Disruptive Innovator? Harmony. http://meetharmony.com/2016/10/14/cannabis-industry-new-disruptor-market/. Published October 14, 2016. Accessed November 21, 2016.
17.
Product. CannaKorp. http://www.cannakorp.com/product/. Accessed November 21, 2016.
18.
Huddleston, Jr. T, Huddleston, Jr.                      Tom. The Legal Pot Market Could Hit $22 Billion in Sales By 2020. Fortune. http://fortune.com/2016/02/01/marijuana-sales-legal/. Published February 1, 2016. Accessed November 18, 2016.
19.
Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells . Science Direct. http://www.sciencedirect.com/science/article/pii/S0308814612018468. Published June 1, 2013. Accessed November 18, 2016.
20.
Hemp fibres “better than graphene” – BBC News. BBC News. http://www.bbc.com/news/science-environment-28770876. Published August 13, 2014. Accessed November 18, 2016.
21.
Scientists mix carbon fibre & hemp for lighter auto parts – The Economic Times. The Economic Times. http://economictimes.indiatimes.com/industry/auto/news/auto-components/scientists-mix-carbon-fibre-hemp-for-lighter-auto-parts/articleshow/45822335.cms. Accessed November 21, 2016.
22.
Chemurgy – The Hemp Body or Soybean Car. Wikipedia. https://en.wikipedia.org/wiki/Chemurgy#The_Hemp_Body_or_Soybean_Car. Accessed November 18, 2016.
23.
Teague C. These Luxury Cars Are Made From Hemp. HERB. http://herb.co/2016/06/11/luxury-cars-hemp/. Published June 11, 2016. Accessed November 21, 2016.
24.
              MintPress News Desk                    . How Hemp Can Clean Up Radiation From Fukushima Nuclear Disaster. MintPress News. http://www.mintpressnews.com/how-hemp-can-can-clean-up-radiation-from-fukushima-nuclear-disaster/210098/. Published October 6, 2015. Accessed November 18, 2016.
Happy Couple prevent Alzheimer's

How Cannabidiol Protects You From Alzheimers Disease

What is Alzheimer’s disease and how could cannabidiol (CBD) protect you from it?

As defined by the Collin’s Dictionary, Alzheimer’s is a disorder of the brain resulting in progressive decline in both intellectual and physical abilities.1

1 in 9 Americans over the age of 65 have Alzheimer’s.2 This degenerative brain condition affects an estimated 5.1 million Americans.3 Truth be told, this is not a normal way to age. With the rapid increase of environmental toxins, societal pressures and other biological stressors this disease has unfortunately become the norm throughout the world.

Clinical symptoms include apathy and depression. As the disease progresses, one may notice disorientation, lack of discernment, behavioral shifts and challenges with speech.

Biologically speaking, Alzheimer’s is the accumulation of beta amyloid plaque in the brain.

What is beta amyloid plaque?

Beta Amyloid plaque is a build up of proteins that leads to the hardening of plaque within the arteries. In a healthy brain these foreign proteins are broken down and thus eliminated from the organ but in a diseased state the brain is overwhelmed and cannot perform this fundamental biological process leading to build up.

It results in far less oxygen being pumped to this vital organ and makes it harder and harder for communication to free flow throughout the brain. There are so many blood vessels in the brain, packed into a relatively small area, feeding and regulating a very complex organ.

Over time, arteries can get very thin in the brain, and it is of vital importance that they are clean, strong and healthy. When they become clogged, we see decline in mental well-being that inevitably leads to Alzheimers. The solution is keeping these channels free and clear.

Studies are now showing the ability of CBD from Cannabis to protect the brain from beta amyloid peptide build up and reactive oxygen species that seem to damage the lipids. It acts as a key anti-oxidant in the brain protecting the RNA and DNA from oxidative damage to these life essential fats.4 This is a key finding because our brain is made mostly of fat and for proper function these fats must remain whole, Un-oxidized and intact.

We see that this non-psychoactive cannabinoid found in cannabis could likely protect the brain from cell death and promote neurogenesis in the hippocampus. This translates to new cell growth in the medial temporal lobe while protecting the brain from inflammation.

There are also findings that suggest THC could be a fundamental player in preventing beta amyloid plaque build up in the brain warding off Alzheimers as well. After conducting an assay of amyloid plaque with THC through lab testing, there is direct interaction of THC and the stopping of amyloid aggregates.5

This could suggest that more of a full spectrum, whole plant extract is best to powerfully put a halt to amyloid plaque build up and Alzheimer’s disease.

The simple fact that our brains have cannabinoid receptors, makes plant cannabinoids the perfect food and nourishment for this vital organ — while helping protect and ward off the debilitating disease, Alzheimer’s.

References:


1.
Alzheimer’s disease | Definition, meaning & more | Collins Dictionary. Collins English DIctionary. http://www.collinsdictionary.com/dictionary/english/alzheimers-disease. Accessed November 6, 2016.
2.
Alzheimer’s Statistics. Alzheimers.net. http://www.alzheimers.net/resources/alzheimers-statistics/. Published 2016. Accessed November 6, 2016.
3.
Alzheimer’s Disease Statistics. Alzheimer’s Foundation of America. http://www.alzfdn.org/AboutAlzheimers/statistics.html. Published January 28, 2016. Accessed November 6, 2016.
4.
Steardo L, Iuvone T, Carratù MR, et al. Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement. PLoS One. 2011;6(12):1. doi: 10.1371/journal.pone.0028668 [Source]
5.
Cao C, Li Y, Liu H, et al. The potential therapeutic effects of THC on Alzheimer’s disease. J Alzheimers Dis. 2014;42(3):973-984. [PubMed]
Marijuana inside your Brain

Marijuana Your Body Makes – Endocannabinoids

Inside your body are millions of cannabinoid receptors. They have one purpose: to receive and process neurotransmitters known as cannabinoids – substances your body naturally produces (called endocannabinoids), and named for the fact that they are found in the cannabis plant, or marijuana.1, 2

In fact, cannabinoid receptor type 1 (referred to simply as CB1) is one of the most abundant G-protein coupled receptors in the human brain.3

CB1 receptors operate in a way that scientists used to believe was impossible: retrograde signaling. That means cannabinoids are the only known brain signals that travel BACKWARDS across the synapse to regulate the signaling neuron.4

Typically, neurotransmitters flow in one direction: from the signaling neuron to the receptor neuron. Messages can travel in both directions during the growth and development of the nervous system, but adult neurons can only fire in one direction. Recently scientists have discovered that cannabinoids actually travel the opposite way – called retrograde signaling.4

When a receptor neuron is being over-stimulated, it can actually send a message backwards – to the signaling neuron, telling it to calm down, and stop signaling so much. The only neurotransmitters that have been found to do this in adult neurons are cannabinoids.4

Why Is There No Lethal Dose For Cannabis?

Cannabis appears to work completely differently in our brains and neurons than any other known substance.

Imagine you have two people talking: a speaker and a listener. Now let’s simulate a drug like morphine on this conversation. Unknown to the speaker, someone has put ear plugs in the ears of the listener. The speaker keeps talking, but the listener doesn’t hear a word.5

Maybe the speaker would start to speak louder, trying to be heard. Maybe they would scream, shout, and wear themselves out trying to be heard by the listener – but all to no effect, since the listener has ear plugs in.

Instead, let’s simulate cannabis on this conversation: Rather than blocking the listener from hearing, we go directly to the speaker and tell them to stop speaking for a bit.67

Now there is no miscommunication, and there is no wasted effort. The speaker simply knows that the listener doesn’t want to listen right now, and so stops trying. This is why cannabis is so effective at treating pain and inflammation. It doesn’t block the pain signal from being “heard”, but rather it can tell pain neurons to quiet down and stop passing on their message.6

The endocannabinoid system allows receiving neurons to regulate their own incoming signals. Unlike conventional neurotransmitters, cannabinoids are neither excitatory (causing more stimulation) nor inhibitory (causing less stimulation) – yet at the same time they are both, since they modulate the incoming signal.8 Cannabinoids simply turn on or off other neurotransmitters, so if they act on an excitatory signal, they function as inhibitors. This is how they treat symptoms like chronic pain, post traumatic stress, and seizures. If they act on an inhibitory signal they function as stimulants, and this is how they treat symptoms like depression or lack of hunger.

Since this is a natural process in our neurons, cannabis based medicines are proving to be extremely effective. There is no lethal dose for any known cannabinoid. This is also due to another key feature of cannabinoids as neurotransmitters, as we will see in the next section.

Water Soluble Vs Fat Soluble

Structure of a typical chemical synapse

Structure of a typical chemical synapse

Conventional neurotransmitters are water-soluble, meaning they dissolve in water and have polarity (they have positive and negative poles).6

Neurotransmitters are usually stored in concentrated packets waiting to be released by the neuron. These vesicles are positioned to release their neurotransmitters very close to their receptors. As already mentioned, they travel only in one direction: from the presynaptic neuron to the postsynaptic neuron.9

When a neuron fires, it sends an electrical signal down its axon to its tips (presynaptic terminals). This causes those packets of neurotransmitters to be released across the gap (synapse) to the recipient (postsynaptic neuron).9

However, cannabinoids are fat-soluble, meaning they DON’T dissolve in water, and they lack conventional polarity. They also are not pre-made or stored anywhere in your neurons.10

When needed, endocannabinoids are rapidly synthesized from components (mostly fats, or lipids) that make up the postsynaptic cell membrane. Then they are released from all over the cell and make their way back to CB1 receptors on the presynaptic neuron.11

Oil and water don’t mix, and the space around your neurons (the extracellular environment) is mostly water. This means that endocannabinoids released from one neuron don’t travel very far, and tend to travel perfectly backwards across the synapse to the signaling neuron (known as retrograde signaling).12

For this reason, cannabinoids and endocannabinoids cannot diffuse or spread throughout the watery extracellular environment of your brain and nervous system. Hence the lack of toxicity with no known lethal dose.1213

Cannabis is an Effective Treatment

Rather than stopping the receiver (postsynaptic neuron) from receiving and passing on the message, cannabinoids regulate the sender of the message (the presynaptic neuron).67

This is why cannabinoids are so effective at treating all kinds of neurological issues; from chronic pain 14, to post traumatic stress (PTSD) 15, to phobias – cannabinoids effectively “turn down the volume” of these undesirable signals.6

In addition, your body only produces and releases endocannabinoids when neurons fire repeatedly – five or even ten times in a row.6 This means it allows you to “get the message” but it stops the message from becoming redundant. This also helps calm the kind of neuronal storms that are associated with epileptic seizures and hyperactivity.16

Yet at the same time, there are little to no side-effects because of the method of action. The signaling neuron won’t exhaust its neurotransmitters in a vain attempt to be heard, and those un-received signals won’t dissolve into the intracellular water – spreading throughout your nervous system. Remember, oil and water don’t mix. Unlike other neurotransmitters which are water soluble, cannabinoids are fat-soluble.

Cannabis is Required For Health

PTSD

Cannabis has proven effective in treating PTSD

Experiments suggest that insufficient release of endocannabinoids is perhaps the root cause of chronic anxiety and post-traumatic stress disorder.17

Large concentrations of cannabinoid receptors have been observed in several of the brains pain centers, indicating that cannabinoids are integral to your body’s own management of pain.18

Cannabinoid receptors (specifically CB1) are the most abundant G-protein coupled receptors in the human brain. Areas responsible for complex motor functions, cognition, learning, memory – are all dense with CB1 cannabinoid receptors.6

Clearly cannabinoids are an important neurotransmitter. However, unlike typical neurotransmitters, they are not pre-synthesized nor are they stored in the neurons. They must be synthesized by components within the cell membrane when they are needed.

So if your diet and lifestyle, environmental factors, or genetics have left your neurons deficient in healthy fats and other components – they cannot produce enough endocannabinoids to modulate signals for pain, fear, desire, learning, cognition, and so on.

This is why cannabis, as a health supplement, is so important for optimal human health. Not only does the cannabis plant contain cannabinoids (phytocannabinoids) that exactly match our own, but the plant also contains the nutrition our bodies need to produce our own endocannabinoids.

This article has only focused on the effects of the CB1 receptors in your brain and nervous system. Yet scientists have also identified cannabinoid receptor type 2 (CB2 receptors) which exist in your immune system, reproductive system, gastrointestinal system, peripheral nervous system, and even in your brain as well.

Our next article will focus on modern research and findings into the functions and benefits of this second major discovery.

References:


1.
Devane W, Dysarz F, Johnson M, Melvin L, Howlett A. Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol. 1988;34(5):605-613. [PubMed]
2.
Pacher P, Bátkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev. 2006;58(3):389-462. [PubMed]
3.
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Could Cannabidiol from Cannabis Kill Breast Cancer Cells?

This article shares sound evidence that Cannabidiol from Cannabis could be a potent player in the reversal of Breast Cancer.

A powerful new discovery is shedding light on a subject that all too often leaves many in the dark, and often fearful in this world.

To put things into perspective breast cancer is the second leading cause of cancer-related deaths in women in The United States. (http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-key-statistics)

Cannabidiol is a therapeutic and non-psychoactive constituent of the Cannabis Sativa plant. It is a key phytocannabinoid (phyto meaning it is plant derived), making up roughly 40% of the cannabis plant’s cannabinoid structure.

We continue to see more and more solid evidence that this cannabinoid plays an active role in reversing and/or preventing breast cancer.

How Could a Plant Prevent Cancer?

Did you know your body has an endocannabinoid system (endo meaning it is naturally occurring within your body)? Within your endocannabinoid system is a group of endogenous cannabinoid receptors; located in the brain and throughout the central and peripheral nervous systems.

CB1 receptors are found in the brain and nervous system while CB2 receptors are mainly found in the body’s immune system.

The phytocannabinoids found in Cannabis fit like lock and key into the brain and body assisting communication between pathways.

When cannabinoids bind with CB2 receptors, they work as immune modulators. They are able to prevent and reduce inflammation (by interrupting the pro-inflammatory cytokine pathway), and are crucial players in removing diseased cells from the body.  

Cannabidiol also shows evidence of being anti-neoplastic – which means it prevents and/or inhibits tumor growth.

An article from the American Association of Cancer Research (noted in the resources section below) suggests that Cytochrome C is a key player in the electron transport to our mitochondria, which provides energy to our bodies. Without this free flow of energy, healthy cells cannot thrive and override the malaise of the disease.

Cytochrome C by definition is a vital component to providing the mitochondria of our cells with energy. If the message is not relayed then disfunction of the cell results.

Furthermore, Cytochrome C assists the apoptosis of breast cancer cells which is of paramount importance to reversing this weakening condition.

The main thing to understand is that our cell mitochondria play a crucial role in warding off cancer cells and DNA mutation. When the mitochondria produce less ATP, the result is often damaged mitochondria. ATP (Adenosine triphosphate) is a way for cells to store and utilize energy.

How could one increase Cytochrome C in an effort to enhance ATP in the mitochondria? The intake of Cannabinoids such as Cannabidiol and other cannabinoids found in Cannabis looks to be a promising way to increase Cytochrome activity in the human body.

Other adjuncts to this would be therapies such as low lever laser therapy. Red light and infrared wavelengths have the ability to penetrate the skin and support cell regeneration. These lasers have been shown to increase cytochrome c and free up energy enhancing cell repair.

By doing our own due diligence and learning how the body works to communicate through its very own endocannabinoid system we can take action and release the fear around this subject, but instead empower one another to true health and well-being.

Resources:

http://mct.aacrjournals.org/content/10/7/1161

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075374/

http://reset.me/study/study-cannabidiol-cbd-kills-breast-cancer-cells/

UK CBD Laws and their meaning to you

New UK CBD Laws – What They Mean For You

The UK recently recognized Cannabis as having medicinal use! They also passed new CBD Laws that may affect you.
The Medicines and Healthcare products Regulatory Agency (MHRA) has found that Cannabidiol (CBD) has a “restoring, correcting or modifying” effect on “physiological functions” when administered to humans.

This is a double-edged sword for the general public:
In the long term, it will lead to regulated, reliable, and ultimately higher quality medicines.
However, in the short term, it may restrict general access to purchasing CBD, and it may also put several smaller CBD companies out of business. Read more

Treating PTSD With Cannabis

According to recent reports, Cannabis can reduce the symptoms of PTSD by 75%. (01)

In fact, some researchers believe that PTSD may actually be caused by an imbalance in the endocannabinoid system.
Patients suffering from PTSD were found to have low or depleted natural levels of Endocannabinoids. (02) Read more