Cancer

From The Cannapedia
Jump to: navigation, search

Cannabinoids directly inhibit tumor growth through several different pathways:

  • They selectively target and kill cancer cells through autophagy and apoptosis. Cannabinoids actually interact with cancer cells on a molecular level and trigger them to self-destruct. All this without causing any harm to surrounding healthy cells, in fact, they protect and improve the health of surrounding cells at the same time.[1] [2]
  • Cannabinoids Shrink Tumors and Prevent Spreading (Metastasis). According to a study published in the British journal of clinical pharmacology in 2013; "Cannabinoids possess anti-proliferative and pro-apoptotic effects and they are known to interfere with tumor neovascularization, cancer cell migration, adhesion, invasion, and metastasization." [3]

Dosing and Safety Information

  • Dosing of cannabis is based on a given patient's weight and type of cannabinoid used and is typically administered at least several times a day.
  • Side effects may include drowsiness and fatigue, agitation and diarrhea. Dosing must be monitored carefully because 10% of patients on high dose THC can experience seizures.
  • Cannabinoids can be administered via a number of delivery systems, depending on the product and purpose of the medication for the individual patient. Administration methods include smoking or vaporizing, eating (edibles), oils (olive, MCT/coconut, safflower), tinctures (alcohol and vegetable glycerin), suppository, and topicals in the form of a patch, gel, salve/cream.

Procuring a Safe Cannabis Product

With medical Cannabis primed to be the next billion dollar business in America, this “green rush” has attracted more than its share of unscrupulous companies/people who are driven by financial gains and not by the best interest of consumers. Patients/parents/caregivers, therefore, must do their due diligence and ask questions before using any cannabis product.

The key to obtaining a legitimate vendor is - know your supplier.

Know the lab that is testing the cannabis product, and know which laboratory tests are needed to ensure a safe product.

Here is a list of common tests you should examine before buying a product:

  • Potency Testing - how concentrated is the product?
  • Microbial Testing - crucial for patients with weak immune systems. The tests will show if any fungus, mold, bacteria, yeast are present in the cannabis product.
  • Residual Solvent Testing - do any residual solvents (Ethanol, Butane, Hexane, and other compounds) remain present in the product?
  • Polycyclic Aromatic Hydrocarbons (PAH) - These substances are classified as carcinogens and genotoxic mutagens. In a recent European study, only 31% of tested CBD oils contained acceptable levels of PAH[4] - so make sure to look for these!
  • Heavy Metal Testing - if grown outdoors, does the product have residual arsenic, mercury or lead? Because of its phytoremediation properties (process whereby plants remove toxic agents from the environment), Hemp absorbs everything from the soil, including any heavy metals such as arsenic, mercury, or lead. However, if your grower uses organic soil and only grows indoors or in a greenhouse, this test is not needed.

In addition, consumers need to become educated on the interpretation of such lab test results.


Anti Tumor


Cancer related pain


Cervical Cancer


Colon Cancer

Colorectal Cancer


Breast Cancer


Brain Cancer - Glioma and Glioblastoma

Gastric Cancer


Kaposi Sarcoma


Kidney Cancer - Renal Cell Carcinoma

Very few studies have focused on the Endocannabinoid System in the kidney and its neoplasms (tumors). In 2010, researchers confirmed the presence of Cannabinoid receptor type 1 (CB1) and the absence of Cannabinoid receptor type 2 (CB2) in human kidneys. This suggests a possible role of the endocannabinoid system in the development and function of the human kidney, and may also indicate possible therapeutic uses of cannabinoids in the treatment of kidney disease, including cancer.

As of 2010, the precise role of cannabinoids in renal cancer still remains to be clarified. Findings were similar to those of colorectal cancer in 2008 and breast cancer in 2006.

Conclusions

This would imply that non-THC cannabinoids (such as CBD) would be more beneficial to the treatment of kidney cancer, and that - perhaps certain doses of THC could increase tumor growth. More research is required.

Clear cell renal cell carcinomas (CCRCCs) show damaged or over-stimulated CB1 receptors (downregulated cannabinoid receptors). THC is an agonist (meaning it binds with and stimulates) CB1 receptors, and so the wrong dose could further damage (downregulate) the CB1 receptors and theoretically speed up tumor growth. Cannabidiol (CBD) is an antagonist to (blocks) THC and it's endocannabinoid analogs (your body's natural versions of THC). So if there is as cannabinoid imbalance within your kidneys, CBD could minimize the damaging effects of the imbalance.

Again, caution is necessary. There is very little clinical evidence of the effects of cannabis on kidney cancer, or renal cell carcinoma.

Experiences

Corrie Yelland of Cannbis Health Radio claims to have had multiple successes in curing Kidney Cancer with high-THC cannabis oil (Rick Simpson Oil method).

One man in his 30's, with stage 4 renal cell carcinoma (kidney cancer) which had metastasized to his gal bladder. He had been given 2 months to live, and within 3 months of Cannabis Oil treatment he was clear of all cancer.

This is anecdotal and not confirmed, however it gives an indication of hope and also of the type of treatment.

References


Leukemia


Lung Cancer

Distribution of demographic and consumption variables for smoking-related cancers.

A study published in 2006 found no positive associations between smoking cannabis and typical smoking-related cancers (head and neck cancers, respiratory tract cancers). This study tracked 2,252 people who smoked an average of 1 joint per day over 30 years. The association of these cancers with marijuana, even long-term or heavy use, is not strong and may be below practically detectable limits. [5]

Donald Tashkin, a professor of pulmonology at UCLA's David Geffin School of Medicine, revealed that components of marijuana smoke, although they damage cells in respiratory tissue, somehow prevent them from becoming malignant. In summary, the accumulated weight of evidence implies far lower risks for pulmonary complications of even regular heavy use of marijuana compared with the grave pulmonary consequences of tobacco. [6]

However, an 8-fold increase in risk was observed in those who mixed cannabis with tobacco. [7]

We suggest caution when inhaling any form of smoke, as even cannabis smoke causes bronchial epithelial ciliary loss and impairs the microbicidal function of alveolar macrophages. [8]

Therefore vaporization would be the optimal method of inhaling cannabis for both medicinal and recreational use.

References


Lymphoma


Pancreatic Cancer

Cannabinoids exert antiproliferative properties in pancreatic ductal adenocarcinoma (PDAC).


Prostate Cancer

Skin Cancer


Thyroid Cancer