Autism - boy covers ears

What’s The Answer to Autism?

In order to understand what is happening in an Autistic individual we must touch upon the critical role of the Endocannabinoid System (ECS).

A low-grade chronic infection is a primary challenge in autistic individuals – resulting in systemic inflammation. A pro-inflammatory state in both the brain and the gut are symptoms of Autism which points to a malfunctioning ECS. 

Our ECS is made up of lipids and receptors and is located in the brain, immune and nervous systems. The ECS regulates physiological systems, including appetite, pain, inflammatory response, thermoregulation, intra-ocular pressure, physical sensation, muscle control, energy balance, metabolism, sleep health, stress responses, motivation/reward, mood, and memory. 1

Autism and its relation to an imbalanced or inefficient ECS is one of the main research findings by the late great Doctor Bradstreet out of Melbourne, Florida. Stanford University research also shows us the powerful link to the ECS and Autism as well as studies put out by The American Society for Experimental NeuroTherapeutics.  2  3

Further research suggests that a gene mutation is present in autistic individuals blocking the body’s natural production of endocannabinoids. 4  This then results in behavioral challenges, issues with psychological development and imbalances in cognition.

Another key finding is that this gene mutation is what causes spastic communication instead of calm communication between pathways, this directly links to an inefficient ECS5

Take for example an Autistic person that displays an addiction to certain foods. The ECS regulates this type of impulse. An imbalanced ECS can cause irregular cravings as well as leaky gut. The ECS controls all of these physiological systems and without sufficient endocannabinoid production, it is challenging for the body to communicate properly.

Autistic individuals are also highly sensitive to environmental toxins because their system does not properly control toxins from passing through the gut lining as well as the blood-brain barrier.

This shows us a direct connection to a weak ECS. Their brain is susceptible to toxins because the ECS in the brain is malfunctioning, allowing toxins to pass the blood brain barrier causing irritation. Cannabinoids – like cannabidiol – help to seal the matrix of the brain and protect the neurovascular environment.    Because our ECS is also a part of the digestive system this same challenge happens with the gut wall; causing irritation and imbalances. It too must be sealed and cannabinoids help to accomplish this. 

With a restored and nourished ECS, a proper foundation is created leading to the healthy signaling of transmitters in the brain and gut.

The Solution:

Cannabinoids are a foundational part of a healthy and optimal functioning body.

Using extracted cannabinoids from the cannabis plant could be a therapeutic approach offered by nature. These fatty acid compounds help to:

  • Nourish the brain – ease inflammation
  • Seal the blood brain barrier from toxins, as well as
  • Heal the protein-tight-junctions in the gut so that pathogens do not get through.

With this improved state of one’s immune system, the signaling can be restored to optimal function and communication can operate in a healthy manner.

Research and real life examples show supplemental usage of cannabis oil helps to calm down these individuals and restore the ECS.

Here is an infographic sharing the importance of a well-nourished endocannabinoid system and its connection to Autism.   

*This article is dedicated to the late Dr. Jeff Bradstreet for his impeccable service to share his findings with the Autistic community.

1.
2.
Endocannabinoid Signaling in Autism. Neurotherapeutics. http://petaleconsultancy.com/Endocannabinoid-Signaling-in-Autism.pdf.
3.
Dr. Jeff B. Understanding the Endocannabinoid System and Autism and therapeutics. Youtube Presentation. https://youtu.be/s8CbIvd8p4Q.
4.
Cannabis shows great promise treating autism. Natural Society. http://naturalsociety.com/cannabis-shows-great-promise-treating-autism-symptoms/.
5.
Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain. Eurekalert. https://www.eurekalert.org/pub_releases/2013-04/cp-mfi040513.php.
group-of-happy-doctors-at-hospital

Yes, Cannabis DOES Cure Cancer

I’m sure the title of this article will anger many people, and that’s ok. Just don’t dismiss this information before you’ve read it. We will present theories, evidence, facts, and hopefully lead you to the same conclusion; that yes, Cannabis really does cure cancer.

NOTE:

This article will be updated regularly to include new research and material as well as addressing objections and questions from skeptics.

There is No Cure for Cancer…

Believing that no cure for cancer exists is based on mistaking the word cure for the word panacea.
To cure simply means “to relieve (a person or animal) of the symptoms of a disease or condition.” 1
Whereas panacea means “a solution or remedy for all difficulties or diseases.” 2

Cannabis in not a panacea. It does not work every time, for every person, on every form of cancer. And yet, that is what too many people hear when we say cannabis cures cancer.

However, cannabis has been shown to cure some forms of cancer in some people some of the time. In fact, based on our research, we are prepared to make the claim that cannabis succeeds in curing cancer more than it fails to cure cancer. Not only does it work more than 50% of the time (some people say it works 80% of the time), it is also used to reduce the negative effects of other forms of cancer treatment, and its side-effects are almost completely positive. Those treated with cannabis have almost zero incidences of reoccurring cancer, and no lasting damage or scarring from the treatment. Let’s examine some of the evidence which supports these claims.

The Facts

Here we present many scientific studies showing the effects of cannabis on cancer in a laboratory setting. We will also cross-examine these facts with genuine questions from skeptics. If we have missed an important question, feel free to leave it in the comments and we can update this article with relevant questions.

Cannabinoids kill cancer cells

 

THC Molecule

A THC Molecule

A common statement made by cannabis supporters is that cannabinoids have been shown to kill cancer cells in laboratory experiments. 3

 

Rebuttal:

So does lemon juice, so does radiation. Just because they kill cancer cells in laboratory experiments doesn’t mean they will kill cancer cells in a human in any way that is beneficial.

Response:

Remarkably, cannabinoids target cancer cells, while non-tumor cells and tissues are avoided. 4
The key is how cannabis targets and kills cancer cells:

Cannabinoids have been shown to Selectively Trigger Autophagy in Cancer Cells

Autophagy is when cells digest and recycle damaged parts of themselves.56
Reduced autophagy is found in tumor cells and may be associated with the transformation of healthy cells into malignant tumor cells,7, 8 and is thought to be a predictor of tumor growth.9
In addition, necrosis and chronic inflammation are controlled and limited by autophagy, as any damage within the cell is consumed as an energy source.10 This helps prevent damaged cells from transforming into malignant tumor cells.101112  Recent research shows autophagy’s role as a tumor suppressor.713

Cannabis has been shown to specifically target tumor cells and trigger autophagy, 141516 while simultaneously protecting nearby healthy cells.17 This means cannabis triggers cancer cells to consume themselves without harming surrounding healthy cells, and in fact, protects healthy cells.4

Cannabinoids have also been shown to Selectively Trigger Apoptosis in Tumor Cells

CBD Molecule

A CBD Molecule

Apoptosis is a kind of programmed cell death mechanism.
Abnormalities in apoptosis that lead to early cell death or the absence of normal cell death have been linked to neurodegenerative disorders and cancer,18 19 as well as cancer cell resistance to chemotherapy.20 21

An important aspect of an effective anti-tumor drug is its ability to inhibit proliferation (rapid reproduction) of cancer cells. Cancer cells proliferate rapidly in an uncontrolled manner. Also, these cells escape death mechanisms which a normal cell undergoes like apoptosis.

Cannabinoids have been shown to selectively trigger apoptosis in tumor cells. 22 23  Cannabinoids actually interact with cancer cells on a molecular level and trigger them to self-destruct.22 All this without causing any harm to surrounding healthy cells, in fact, they protect and improve the health of surrounding cells at the same time.4

They have exhibited these anti-proliferative and apoptotic effects on every form of cancer tested so far, including (but not limited to):

  • Bone cancer 22
  • Breast cancer 2223
  • Colon cancer 2324
  • Cervical cancer 25
  • Gastric cancer 26
  • Glioma (brain) cancer 2223
  • Head and neck cancer
  • Lung cancer 2223
  • Leukemia 2723
  • Lymphoma 2223
  • Oral cancer 22
  • Pancreatic cancer 22
  • Prostate cancer 22
  • Skin cancer 22
  • Thyroid carcinoma 2223

The powerful apoptotic and autophagic properties of certain cannabinoids has resulted in them being referred to as anti-tumor agents even among cancer researchers.3 The important fact to point out here is that cannabis has these anti-tumor effects without damaging any other cells in the body. Cannabis is anti-tumor while actually increasing the health of the rest of the body.4 28

 

Model of tumorigenesis

Model of tumorigenesis. The figure illustrates the formation of an invasive tumor and its metastasization to a distant organ via a blood vessel. Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Cannabinoids Shrink Tumors and Prevent Spreading (Metastasis)

According to a study published in the British journal of clinical pharmacology in 2013; “Cannabinoids possess anti-proliferative and pro-apoptotic effects and they are known to interfere with tumor neovascularization, cancer cell migration, adhesion, invasion, and metastasization.” 23

Rebuttal:

Awaiting rebuttal.

Response:

In addition to the anti-proliferative (autophagic) and pro-apoptotic effects of cannabinoids, they are also known to interfere with tumor neovascularization, cancer cell migration, adhesion, invasion, and metastasization.23

Let’s look at each of these categories in more detail.

Tumor Vascularization

Tumours can grow to a size of approximately 1–2 mm3 before requiring direct blood flow.29  Tumor Vascularization is when a tumor is able to attract the growth of blood vessels from the supportive tissue around itself. Getting sufficient blood and oxygen is critical for tumor growth.

Studies are showing that cannabinoids can drastically reduce the growth of tumors by specifically inhibiting tumor vascularization – amazingly these effects are limited to cancerous cells.30 31  So cannabinoids prevent tumors from growing by directly preventing them from attracting blood vessels to themselves, without interfering with vascularization of surrounding healthy tissue.4

 

Tumor Cell Migration and Metastasis

When tumor cells detach from their surrounding tissue and migrate to other areas of the body (metastasis), they must rely on autophagy for their energy.32

Cannabinoids have been shown to selectively switch off autophagy specifically in tumor cells that have detached and begun migrating.3233  Thus cannabinoids both encourage autophagy in tumor cells when static, and discourage autophagy in tumor cells when metastatic – showing amazing adaptability in fighting cancer.34, 3536

Overview on the functional effects of Cannabinoids on Tumor Cell Migration

CannabinoidTumor TypeRegulation of Functional EffectSignal TransductionReferences
AEABreastReduced MigrationCB1 receptorJoseph et al., 2004 33
2-AGCervicalReduced MigrationCB1 receptorRudolph et al., 2008 37
THCCervicalReduced MigrationCB1 receptorRudolph et al., 2008 37
THCColonReduced MigrationCB1 receptorJoseph et al., 2004 33
THCGlioma, AstrocytomaReduced MigrationUnknownBlázquez et al., 2008 36
CBDGliomaReduced MigrationIndependent of G-protein-coupled receptorsVaccani et al., 2005 34
THCLungReduced MigrationInhibition of EGF-induced ERK1/2, JNK, AKT; increased phosphorylation of FAKPreet et al., 2008 35

– Antitumorigenic Effects of Cannabinoids beyond Apoptosis 38

 

Cancer Cell Adhesion

Cells in our bodies have what are known as Cell Adhesion Molecules (CAM) that allow them to attach to other tissues of the body.39  The ability of cancer cells to metastasize and spread to new areas of the body relies upon these cell adhesion molecules.40 Disrupting the CAMs of tumor cells has been widely researched as an effective anti-cancer therapy.41, 42

Cannabinoids have been shown to be effective at inhibiting the adhesion and invasion of cancerous cells throughout the body.38, 43, 35  These effects are noticed only in tumor cells and does not appear to affect the CAMs of healthy cells. 4 43

Overview on the functional effects of Cannabinoids on Tumor Cell Adhesion

CANNABINOIDTUMOR TYPEFUNCTIONAL EFFECTSIGNAL TRANSDUCTIONREFERENCES
THCAstrocytomaReduced AdhesionCannabinoid receptor-independent blockade of IL-1-induced up-regulation of cell adhesion moleculesCurran et al., 2005 44
THCBreastReduced AdhesionCB1 receptor; inhibition of FAK-, and Src-phosphorylation on collagen type IVGrimaldi et al., 2006 43
THCGliomaReduced AdhesionBlockade of IL-1-induced up-regulation of cell adhesion moleculesCurran et al., 2005 44
THCNeuroblastomaReduced AdhesionCB1 receptor; up-regulation of FRNK phosphorylationZhou et al., 2002 45

– Antitumorigenic Effects of Cannabinoids beyond Apoptosis 38

Tumor Cell Invasion

Intravasation is the invasion of cancer cells through the basal membrane into a blood or lymphatic vessel. Invasion and metastasis are the greatest obstacles to successful tumor treatment.46  The greater the ability of a cancer cell to invade other membranes, the more malignant the cancer is considered.47

Cannabinoids have been shown to reduce the invasiveness of cancer cells, with some researchers even calling THC “anti-invasive” in reference to its cancer fighting ability. 48, 49, 50  Cannabinoids may therefore offer a therapeutic option in the treatment of highly invasive cancers without risk of damaging healthy cells.4 48

Overview on the functional effects of Cannabinoids on Tumor Cell Invasion

CANNABINOIDTUMOR TYPEFUNCTIONAL EFFECTSIGNAL TRANSDUCTIONREFERENCES
CBDBreastReduced InvasionId-1 down-regulationMcAllister et al., 2007 51
THCCervicalReduced InvasionCB1, CB2 receptors; TIMP-1 up-regulationRamer & Hinz, 2008 48
THCLungReduced InvasionCB1, CB2 receptors; TIMP-1 up-regulationRamer & Hinz, 2008 48
THCLungReduced InvasionInhibition of EGF-induced ERK1/2, JNK, AKT; increased phosphorylation of FAKPreet et al., 2008 35
2-AGProstateReduced InvasionCB1Nithipatakom et al., 2004 50

– Antitumorigenic Effects of Cannabinoids beyond Apoptosis 38

Tumor Metastases

Tumor cell migration, adhesion, and invasion are all parts of the progression of metastases. Collectively, cannabinoids reduce the expansion of tumor cells in several ways that are not yet fully understood. What is clear is that cannabinoids are antimetastatic – and cannabinoids prevent the spread of cancer in addition to killing cancer cells.38

Overview on the functional effects of Cannabinoids on Tumor Cell Metastasization

CANNABINOIDTUMOR TYPEFUNCTIONAL EFFECTSIGNAL TRANSDUCTIONREFERENCES
CBDBreastReduced MetastasesCa2+, ROSLigresti et al., 2006 52
AEABreastReduced MetastasesCB1 receptorGrimaldi et al., 2006 43
THCBreastDecreased Cell ProliferationUnknownSchlumpf et al., 2008 53
AEALungReduced MetastasesCB1 receptorPortella et al., 2003 54
THCLungReduced Metastasesnhibition of FAK-, ERK1/2- and Akt-phosphorylationPreet et al., 2008 35
THCSkin CancerReduced MetastasesInhibition of the Akt signal transduction pathwayBlázquez et al., 2006 55

 

Conclusion:

When an oncologist attempts to target a cancerous growth for treatment, they must understand what type of cancer it is, what stage it is in, where it is in the body, and more. One treatment that kills certain types of tumor cells may increase the growth and spread of other types of tumor cells. This is why oncology is such a difficult science.

The research presented here indicates that the cannabis plant contains compounds (cannabinoids) that can fight (apoptosis), prevent (autophagy), and even reverse (triggered autophagy) most types of tumor cells in addition to preventing the spread of cancer throughout the body (cancer cell migration, metastasization). All of this is achieved while causing no harm to healthy cells.4 28

It’s almost as if our body knows how to heal itself, and cannabis gives our body the tools it needs to heal itself of cancer.

The witnesses we present next will provide evidence that consuming the cannabis plant in a concentrated oil form delivers many different cannabinoids to the body. When given these cannabinoids in their natural form, they appear to help the body fight, prevent, and reverse cancer without the direction of an oncologist or any other specialist. We propose, based on this evidence, that cannabis simply helps increase the body’s natural defenses against all forms of cancer.

The Witnesses

Here we present testimony from several people who claim to have cured their cancer using cannabis oil. We will also cross-examine these witnesses with genuine questions from skeptics.

Sharon Kelly

Sharon Kelly poses with her scans before and after using cannabis oil

Sharon Kelly poses with her scans before and after using cannabis oil

54-year-old Sharon Kelly was diagnosed with non-small-cell lung cancer. She was told that the cancer in her body had made its way to her lymph nodes and the lining of her stomach; and that she could expect to survive for somewhere between six and nine months.

She was informed that radiation and chemo-therapy were not valid treatment options for a patient with stage four lung cancer, as they would likely only make her sicker. Instead, they urged her to return home to husband and children to enjoy her remaining 9 months of life.

Without adequate help from the medical community, Kelly’s youngest daughter turned to the internet and began reading numerous testimonials from cancer patients who had found relief with cannabis oil. With nothing left to lose, Kelly decided to try it for herself and began taking a small dose orally several times a day.

After noting how tired she became after taking the oil orally, she began researching cannabis suppositories, or drug-administration systems that are inserted into the rectum, vagina or urethra. She found that this method didn’t make her tired, and that it allowed her to take the full recommended dose without complication.

She eventually upped her dosage to two grams per day, and paired the treatment with an alkalizing, clean-eating diet. Within a few months, her tumor had shrunk from 5cm to 2.1cm and her lymph nodes had retained their normal size. Her doctors noted the fluid surrounding her heart was also no longer visible.

After seven months of cannabis oil treatment, Kelly’s scans indicated she was completely cancer-free, shocking her oncologist and others familiar with her case. Now, 13 months after her initial diagnosis, Kelly remains cancer-free, and credits the use of cannabis oil for not only her otherwise unexplained recovery, but also her ability to live out the rest of her life amidst the love and comfort of her family.56

Corrie Yelland

Corrie Yelland in 2012In July of 2011, Corrie Yelland was diagnosed with Anal Canal Cancer (the same form of cancer that took Farrah Fawcett’s life). Following 2 surgeries, her cancer still remained. The only option offered was to endure a regime of radiation treatments.

The Anal Canal is considered “the worst area of the body to radiate.” The radiation beam will hit both the coccyx and pubic bone; potentially causing permanent damage.

Corrie was told she would suffer 2nd and 3rd degree burns vaginally, rectally, across her buttocks, as well as her entire “nether regions.” Additionally, there was a “good possibility” both her vagina and rectum would fuse shut from the burns and subsequent scarring.

Corrie told her doctor that she needed time to think it over before agreeing to the procedure. However, without treatment she was given only 2-4 months, possibly 6 months to live.

One day, Corrie was given a copy of Run From The Cure – by Rick Simpson. She describes what happened next:

“Here was this man, a seemingly super straight small town Nova Scotian, talking about these amazing results he had seen with in himself and other people taking Cannabis and curing themselves of a myriad of diseases including end stage cancers.
After hearing what Rick had to say, and watching the testimonials in the video, I was feeling some hope for the first time. For 2 weeks I did nothing but research cannabis as a medicine. I was stunned by the sheer number of studies on Pub Med indicating that cannabis indeed has the capacity to heal. I started using cannabis 2 months ago as per Rick Simpson’s protocol from his video. (He recommends starting out small, and slowly upping the dose so ones’ body becomes accustomed to it, without being high constantly. As a person who hasn’t smoked pot since my late teens, early 20’s, the non-high aspect appealed to me). I had huge hopes to cure my cancer, and embarked on my fight to live.”

She also began filling gelatin capsules with a mixture of the cannabis oil and olive oil and inserting them rectally. 2 weeks into the cannabis oil regime, Corrie noticed most of her pain was gone. Typically needing 10-15 Tylenol per day, she was down to just 1/2 a tablet per day.

On September 20, 2012, she returned to her surgeon. He examined her a total of 3 times just to make sure of the results. Finally his prognosis:

“It’s gone! I can’t find anything at all. If it wasn’t for the scar tissue I would never have known you had ever had cancer.”

No doctor, no radiation or chemotherapy, and Corrie had successfully cured her cancer with cannabis oil. 57

Here is Corrie’s official medical documentation:

The Verdict

If any of the information presented in this article is inaccurate, please contact us with corrections. If new information is discovered, please contact us with that information. However, until such new evidence is presented to us, we confidently declare:

Yes, Cannabis Does Cure Cancer.

Science is not just for “scientists” to do in a laboratory. Science is the only way to establish something as true or false, and experiments can be done in a lab or on a kitchen table. We have taken you through the scientific method in this article:

  1. We proposed a Hypothesis.
  2. We then tested this hypothesis by examining known facts and interviewing witnesses.
  3. Finally, it comes down to you to analyze whether the evidence supports our hypothesis or not.

Don’t let anyone tell you what is true or false, especially when your health or your life might depend upon it. Test their statement, analyze the evidence, and then decide for yourself.

If you enjoyed this article, please leave us a comment below (way below – there’s a LOT of references). Also, please share this information with anyone who might find it interesting.

Right now, cannabis is not legal for Millions of people to access. And those who can access it may not have access to reliable sources. The only way to change all of that is to spread accurate information about this plant. Educate yourself first, and then help us to educate others!

 

Thank you for your time and attention.
Sincerely,
DJ Nicke

 


References:

1.
cure – definition of cure in English | Oxford Dictionaries. Oxford Dictionaries | English. https://en.oxforddictionaries.com/definition/cure. Accessed December 17, 2016.
2.
panacea – definition of panacea in English | Oxford Dictionaries. Oxford Dictionaries | English. https://en.oxforddictionaries.com/definition/panacea. Accessed December 17, 2016.
3.
Velasco G, Sánchez C, Guzmán M. Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer. 2012;12(6):436-444. doi: 10.1038/nrc3247
4.
Khan M, Sobocińska A, Czarnecka A, Król M, Botta B, Szczylik C. The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory. CPD. 2016;22(12):1756-1766. doi: 10.2174/1381612822666151211094901
5.
Levine B, Klionsky D. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004;6(4):463-477. [PubMed]
6.
Mizushima N. Autophagy: process and function. Genes & Development. 2007;21(22):2861-2873. doi: 10.1101/gad.1599207
7.
Choi KS. Autophagy and cancer. Exp Mol Med. 2012;44(2):109. doi: 10.3858/emm.2012.44.2.033
8.
Mathew R, Karantza-Wadsworth V, White E. Role of autophagy in cancer. Nat Rev Cancer. 2007;7(12):961-967. doi: 10.1038/nrc2254
9.
Marino G, Salvador-Montoliu N, Fueyo A, Knecht E, Mizushima N, Lopez-Otin C. Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3. Journal of Biological Chemistry. 2007;282(25):18573-18583. doi: 10.1074/jbc.m701194200
10.
Mathew R, Kongara S, Beaudoin B, et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes & Development. 2007;21(11):1367-1381. doi: 10.1101/gad.1545107
11.
Karantza-Wadsworth V, Patel S, Kravchuk O, et al. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes & Development. 2007;21(13):1621-1635. doi: 10.1101/gad.1565707
12.
Degenhardt K, Mathew R, Beaudoin B, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell. 2006;10(1):51-64. doi: 10.1016/j.ccr.2006.06.001
13.
Kaza N, Kohli L, Roth KA. Autophagy in Brain Tumors: A New Target for Therapeutic Intervention. Brain Pathology. 2011;22(1):89-98. doi: 10.1111/j.1750-3639.2011.00544.x
14.
Salazar M, Carracedo A, Salanueva ÍJ, et al. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest. 2009;119(5):1359-1372. doi: 10.1172/jci37948
15.
Koay LC, Rigby RJ, Wright KL. Cannabinoid-induced autophagy regulates suppressor of cytokine signaling-3 in intestinal epithelium. AJP: Gastrointestinal and Liver Physiology. 2014;307(2):G140-G148. doi: 10.1152/ajpgi.00317.2013
16.
Armstrong JL, Hill DS, McKee CS, et al. Exploiting Cannabinoid-Induced Cytotoxic Autophagy to Drive Melanoma Cell Death. Journal of Investigative Dermatology. 2015;135(6):1629-1637. doi: 10.1038/jid.2015.45
17.
Noonan D. How Medical Marijuana’s Chemicals May Protect Cells. Scientific American. https://www.scientificamerican.com/article/how-medical-marijuana-s-chemicals-may-protect-cells/. Published February 1, 2015. Accessed December 17, 2016.
18.
Thompson C. Apoptosis in the pathogenesis and treatment of disease. Science. 1995;267(5203):1456-1462. doi: 10.1126/science.7878464
19.
Nelson DA. Hypoxia and defective apoptosis drive genomic instability and tumorigenesis. Genes & Development. 2004;18(17):2095-2107. doi: 10.1101/gad.1204904
20.
Apoptosis Is Inversely Related to Necrosis and Determines Net Growth in Tumors Bearing Constitutively Expressed myc, ras, and HPV Oncogenes. American Journal of Pathology, Vol. 144, NVo 5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887373/pdf/amjpathol00065-0205.pdf. Published May 1994. Accessed December 17, 2016.
21.
Yang L, Mashima T, Sato S, et al. Predominant Suppression of Apoptosome by Inhibitor of Apoptosis Protein in Non-Small Cell Lung Cancer H460 Cells | Cancer Research. Cancer Research. http://cancerres.aacrjournals.org/content/63/4/831.long. Published February 15, 2003. Accessed December 17, 2016.
22.
Chakravarti B, Ravi J, Ganju RK. Cannabinoids as therapeutic agents in cancer: current status and future implications. Oncotarget. 2014;5(15):5852-5872. doi: 10.18632/oncotarget.2233
23.
Massi P, Solinas M, Cinquina V, Parolaro D. Cannabidiol as potential anticancer drug. Br J Clin Pharmacol. 2013;75(2):303-312. doi: 10.1111/j.1365-2125.2012.04298.x
24.
Izzo AA, Camilleri M. Cannabinoids in intestinal inflammation and cancer. Pharmacological Research. 2009;60(2):117-125. doi: 10.1016/j.phrs.2009.03.008
25.
Lukhele ST, Motadi LR. Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells. BMC Complement Altern Med. 2016;16(1). doi: 10.1186/s12906-016-1280-0
26.
Miyato H, Kitayama J, Yamashita H, et al. Pharmacological Synergism Between Cannabinoids and Paclitaxel in Gastric Cancer Cell Lines. Journal of Surgical Research. 2009;155(1):40-47. doi: 10.1016/j.jss.2008.06.045
27.
Lee C-Y, Wey S-P, Liao M-H, Hsu W-L, Wu H-Y, Jan T-R. A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells. International Immunopharmacology. 2008;8(5):732-740. doi: 10.1016/j.intimp.2008.01.018
28.
Bifulco M. Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth. The FASEB Journal. October 2001. doi: 10.1096/fj.01-0320fje
29.
Hillen F, Griffioen AW. Tumour vascularization: sprouting angiogenesis and beyond. Cancer Metastasis Rev. 2007;26(3-4):489-502. doi: 10.1007/s10555-007-9094-7
30.
Hermanson DJ, Marnett LJ. Cannabinoids, endocannabinoids, and cancer. Cancer Metastasis Rev. 2011;30(3-4):599-612. doi: 10.1007/s10555-011-9318-8
31.
Marijuana Cuts Lung Cancer Tumor Growth In Half, Study Shows. American Association for Cancer Research. https://www.sciencedaily.com/releases/2007/04/070417193338.htm. Published April 17, 2007. Accessed December 17, 2016.
32.
Fung C, Lock R, Gao S, Salas E, Debnath J. Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival. Molecular Biology of the Cell. 2007;19(3):797-806. doi: 10.1091/mbc.e07-10-1092
33.
Joseph J, Niggemann B, Zaenker K, Entschladen F. Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. Cancer Immunol Immunother. 2004;53(8). doi: 10.1007/s00262-004-0509-9
34.
Vaccani A, Massi P, Colombo A, Rubino T, Parolaro D. Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. British Journal of Pharmacology. 2005;144(8):1032-1036. doi: 10.1038/sj.bjp.0706134
35.
Preet A, Ganju RK, Groopman JE. Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene. 2007;27(3):339-346. doi: 10.1038/sj.onc.1210641
36.
Blázquez C, Carracedo A, Salazar M, et al. Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? Neuropharmacology. 2008;54(1):235-243. doi: 10.1016/j.neuropharm.2007.06.021
37.
Rudolph MI, Boza Y, Yefi R, et al. The Influence of Mast Cell Mediators on Migration of SW756 Cervical Carcinoma Cells. J Pharmacol Sci. 2008;106(2):208-218. doi: 10.1254/jphs.fp0070736
38.
Freimuth N, Ramer R, Hinz B. Antitumorigenic Effects of Cannabinoids beyond Apoptosis. Journal of Pharmacology and Experimental Therapeutics. 2009;332(2):336-344. doi: 10.1124/jpet.109.157735
39.
Edelman G. Cell adhesion molecules. Science. 1983;219(4584):450-457. doi: 10.1126/science.6823544
40.
Lafrenie R, Buchanan M, Orr F. Adhesion molecules and their role in cancer metastasis. Cell Biophys. 1993;23(1-3):3-89. [PubMed]
41.
Okegawa T, Pong R, Li Y, Hsieh J. The role of cell adhesion molecule in cancer progression and its application in cancer therapy. Acta Biochim Pol. 2004;51(2):445-457. [PubMed]
42.
Bendas G, Borsig L. Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins. International Journal of Cell Biology. 2012;2012:1-10. doi: 10.1155/2012/676731
43.
Grimaldi C, Pisanti S, Laezza C, et al. Anandamide inhibits adhesion and migration of breast cancer cells. Experimental Cell Research. 2006;312(4):363-373. doi: 10.1016/j.yexcr.2005.10.024
44.
Curran NM. The Synthetic Cannabinoid R(+)WIN 55,212-2 Inhibits the Interleukin-1 Signaling Pathway in Human Astrocytes in a Cannabinoid Receptor-independent Manner. Journal of Biological Chemistry. 2005;280(43):35797-35806. doi: 10.1074/jbc.m507959200
45.
Zhou D, Song Z. CB1 cannabinoid receptor-mediated tyrosine phosphorylation of focal adhesion kinase-related non-kinase. FEBS Letters. 2002;525(1-3):164-168. doi: 10.1016/s0014-5793(02)03091-0 [Source]
46.
Liotta LA, Stetler-Stevenson WG, Murphy AN, Aznavoorian S. Molecular Aspects of Tumor Cell Invasion and Metastasis. Cancer. 1993;71(4):1368-1383. https://www.researchgate.net/profile/Anne_Murphy/publication/229560777_Molecular_aspects_of_tumor_invasion_and_metastasis/links/5456570a0cf2cf5164802f27.pdf.
47.
Behrens J. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. The Journal of Cell Biology. 1989;108(6):2435-2447. doi: 10.1083/jcb.108.6.2435
48.
Ramer R, Hinz B. Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1. JNCI Journal of the National Cancer Institute. 2007;100(1):59-69. doi: 10.1093/jnci/djm268
49.
Blazquez C. Inhibition of tumor angiogenesis by cannabinoids. The FASEB Journal. January 2003. doi: 10.1096/fj.02-0795fje
50.
Nithipatikom K. 2-Arachidonoylglycerol: A Novel Inhibitor of Androgen-Independent Prostate Cancer Cell Invasion. Cancer Research. 2004;64(24):8826-8830. doi: 10.1158/0008-5472.can-04-3136
51.
McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez P-Y. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Molecular Cancer Therapeutics. 2007;6(11):2921-2927. doi: 10.1158/1535-7163.mct-07-0371
52.
Ligresti A. Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma. Journal of Pharmacology and Experimental Therapeutics. 2006;318(3):1375-1387. doi: 10.1124/jpet.106.105247
53.
von B, Schlumpf M, Lichtensteiger W. Delta(9)-tetrahydrocannabinol inhibits 17beta-estradiol-induced proliferation and fails to activate androgen and estrogen receptors in MCF7 human breast cancer cells. Anticancer Res. 2008;28(1A):85-89. [PubMed]
54.
Portella G. Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. The FASEB Journal. July 2003. doi: 10.1096/fj.02-1129fje
55.
Blazquez C, Carracedo A, Barrado L, et al. Cannabinoid receptors as novel targets for the treatment of melanoma. The FASEB Journal. 2006;20(14):2633-2635. doi: 10.1096/fj.06-6638fje
56.
Meet the Woman Who Beat Lung Cancer With Cannabis Oil. Medical Jane. https://www.medicaljane.com/2015/06/11/meet-the-woman-who-beat-her-lung-cancer-with-cannabis-oil/. Published June 11, 2015. Accessed December 21, 2016.
57.
The Corrie Yelland Story: Beating Anal and Skin cancer with cannabis oil. http://CureYourOwnCancer.org. http://www.cureyourowncancer.org/corrie-yellands-story-beating-anal-and-skin-cancer-with-cannabis-oil.html. Published March 2012. Accessed December 22, 2016.
Old man suffers heart attack with grandson

What Everyone Must Know About Cannabis and Heart Disease

Increasing evidence is showing that CBD from the Cannabis plant is beneficial for cardiovascular conditions such as atherosclerosis and heart disease. Most testing has been done on cannabidiol (CBD) and THC, yet other cannabinoids such as Anandamide have also been found to have positive effects on heart conditions.

Heart disease is the leading cause of death in the United States, taking an estimated 788,000 lives per year in 2011.  Cardiovascular diseases take out more lives than all cancers combined.1 

Relaxing Arterial Walls

One of the main findings is how CBD helps to relax arterial walls, lessening tension in the blood vessels. 2 While it relaxes it also protects the arteries from inflammation.3  CBD is a natural way to reduce the metabolic issues of high glucose responses present in heart disease patients as well as diabetes, decreasing vein wall permeability.4

Reducing Inflammation

In heart disease and cardiovascular conditions, there is too much inflammation. New lab tests show the immune modulating and anti-inflammatory components of cannabinoids, coupled with the anti-oxidant effects, protect the heart specifically when tissue damage is present from lack of oxygen and blood supply. 

It also protects the heart from cardiomyopathy – a disease of the heart muscles causing hardening and thickening and lack of blood flow. 2 A very interesting finding was that CBD stopped endotoxin production.  These types of pro-inflammatory cytokines are exactly what cause heart conditions to progress; so inhibiting endotoxin production is a profound key to heart disease and other cardiovascular conditions. 5

Reducing Arterial Plaque

Arterial Plaque is a huge factor in heart disease, atherosclerosis, and cardiovascular issues. When this plaque builds up throughout the arterial walls it makes it very challenging for the heart to pump blood. 

CBD also decreased the adhesion of plaque to arterial walls. This is a key finding, as this type of plaque build-up is one of the main causes of the progression of heart disease. 

The Research Is In…

Research and studies are showing a direct link between treating or even preventing health challenges like atherosclerosis – and the endocannabinoid system.  A study was conducted utilizing tetrahydrocannabinol (or THC) on mice. It was evident that THC activated the CB2 receptors, which inhibited plaque formation within the arteries of the mice. Lab testing further revealed that low oral doses of THC, at about 1mg per day, resulted in the plaque build-up within the arteries halting its progression.6

We are seeing more and more studies suggest that our endocannabinoid system plays a large role in our body’s defense against cardiovascular diseases. 

In summary, CBD has the ability to calm inflammation in the vascular system, relax the arterial walls and work as an immune modulator and anti-oxidant while decreasing the amount of plaque build up in the walls of the arteries. These findings suggest yet another potent use for cannabinoids and cannabis.

Find out what forms of cannabis are legal where you live, and fight for the legalization of those that are not. Your life, or the life of someone you love, could very well be saved by this plant one day.

1.
Heart Disease: Scope and Impact. theheartfoundation.org. http://www.theheartfoundation.org/heart-disease-facts/heart-disease-statistics/.
2.
Is the cardiovascular system a therapeutic target for cannabidiol? NCBI. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579247/.
3.
Is the cardiovascular system a therapeutic target for cannabidiol? NCBI . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579247/.
4.
The potential use of cannabidiol in the therapy of metabolic syndrome. akademiai. http://www.akademiai.com/doi/abs/10.1556/OH.2012.29308.
5.
Role of bacterial endotoxin in chronic heart failure: the gut of the matter. Pub Med. https://www.ncbi.nlm.nih.gov/pubmed/17510602.
6.
Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature. http://www.nature.com/nature/journal/v434/n7034/abs/nature03389.html.